Research Associate in Metabolomics

Imperial College London - Institute of Clinical Sciences

About the role:

This post provides dedicated expertise in Mass Spectrometry Imaging (MSI) within the Metabolomics Facility. The post holder will lead the facility’s MSI capability, delivering spatially resolved metabolomics, lipidomics, and drug distribution studies across a wide range of biological systems.

The role combines method development, project delivery, and user training, working closely with research groups to generate high-quality and reproducible MSI datasets. The post holder will work primarily with AP-MALDI coupled to a high-resolution Orbitrap platform, alongside complementary MALDI MSI instrumentation.

The post provides a unique opportunity to work with cutting edge metabolomics techniques and to become deeply involved in the diverse research topics across ICS.

What you would be doing:

The post holder will work in the Metabolomics Facility, led by Mariana Santos providing dedicated expertise in MSI-based metabolomics to advance a wide range of biological research projects. The post holder will lead the development, optimisation, and delivery of MSI workflows - including sample preparation, instrument operation, data acquisition, and analysis - identifying areas where innovation is needed and driving method development to address scientific challenges. They will also ensure optimal instrument performance, troubleshoot technical issues, and maintain robust and reproducible datasets. They will collaborate closely with internal research groups to advise on experimental design, sample preparation, data interpretation and will work alongside LC-MS and GC-MS colleagues to provide integrated spatial and bulk metabolomics where appropriate. The role also involves providing training and guidance to postdoctoral researchers, PhD students, and research staff, contributing to publications and presentations; and maintaining high standards of record keeping, SOPs, QC workflows, and data management.

What we are looking for:

The successful candidate will have hands-on experience with high-resolution mass spectrometry platforms and a strong understanding of MSI principles, including sample preparation and instrument operation. They will demonstrate experience in metabolomics data analysis, including targeted and untargeted approaches and the application of appropriate statistical methods (e.g. univariate and multivariate analyses, power calculations, and significance testing).

The candidate should have the ability to design, implement, and optimise analytical workflows, and to plan and execute experiments independently. The role requires excellent organisational and time-management skills, and the capacity to work collaboratively with researchers while communicating complex scientific concepts to non-specialist audiences. All applicants should have a PhD degree in Analytical Chemistry, Life Sciences or equivalent experience.

What we can offer you:

• The opportunity to lead and further develop the MSI capability within the Metabolomics Facility and continue career at world-leading institution
• Collaborations with multiple research groups across the ICS and the College, contributing to a wide range of biological research programmes
• Opportunities for continued professional development
• Benefit from sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes)
• Get access to a range of workplace benefits, including a flexible working policy from day 1, generous family leave packages, on-site leisure facilities and a cycle-to-work scheme
• Interest-free season ticket loan schemes for travel
• Be part of a diverse, inclusive, and collaborative work culture with various staff networks and resources designed to support your personal and professional well-being.

Further Information

This is a full-time, fixed term post for 3 years.

For an informal chat about the role, please contact Dr Mariana Santos (m.santos@lms.mrc.ac.uk)