Research Associate - Mechanisms of G protein-coupled receptor (GPCR) activation

A Research Associate position is available in the group of Prof. Daniel Nietlispach at the Department of Biochemistry, University of Cambridge, to study functional aspects of GPCR activation. The position is funded for 3-years by the BBSRC as part of a collaborative project to develop a molecular model of GPCR basal activity and inverse agonism and provides an exciting opportunity to use structural biology and biophysics methods to investigate fundamental aspects of how these receptors work.

The structural and biophysical investigations will be complemented through collaboration with the Ladds lab at the Department of Pharmacology (Cambridge), which will focus on the cellular aspects of the project. As such the role holder will join a team of postdocs and students with whom they will closely work together, while leading their side of the project.

The role holder is expected to be highly skilled in two of the following areas: (i) solution-state NMR spectroscopy, (ii) applied biophysics, (iii) computational modelling, (iv) membrane protein expression/purification and molecular biology. An active interest in GPCRs, membrane protein function or the role of protein dynamics for receptor function is advantageous but not essential. The successful candidate will be highly motivated and help design, conduct and interpret experiments in discussion with the PI, co-PI and other members of the research team.

Candidates should hold a PhD in Biochemistry, Biophysics, Chemistry or another relevant subject.

Fixed-term: The funds for this post are available until 31st December 2028 in the first instance.

To apply online for this vacancy and to view further information about the role, please click the Apply button above. For informal enquiries, please contact Professor Daniel Nietlispach via: dn206@cam.ac.uk. For queries regarding the application process, please contact the Biochemistry HR Team via: personnel@bioc.cam.ac.uk. Please quote reference PH47537 on your application and in any correspondence about this vacancy.