University-Level Unit: Science
Faculty/Department-Level Unit: Pharmacy and Pharmaceutical Sciences
Employee Category: Research Staff
Location_ONB: Kent Ridge Campus
Posting Start Date: 11/11/2026
Job Description
We are seeking a highly motivated and independent Research Fellow to join our research team investigating the molecular mechanisms underlying tumour immune evasion. The project aims to identify and functionally characterise genes that enable cancer cells to evade immune surveillance, with the goal of discovering novel therapeutic targets and developing innovative immunotherapeutic strategies.
Key Responsibilities:
- Independently design, execute and interpret experiments to identify and characterise genes involved in tumour immune evasion.
- Conduct molecular and cellular biology experiments, including gene editing, functional screening and immune cell-based assays.
- Perform mechanistic studies using relevant cancer cell models and, where appropriate, patient-derived organoid and animal models.
- Analyse and interpret experimental data, prepare scientific manuscripts and present research findings at scientific meetings.
- Contribute to grant applications and collaborative research projects.
Career Development Opportunities
The successful candidate will join an active translational research programme with opportunities to develop scientific independence, lead publications, contribute to intellectual property development and participate in collaborative projects. Opportunities will also be available for overseas laboratory training and international collaboration through the EMBO Global Investigator Network (GIN) award, supporting the candidate's scientific development and long-term career progression.
Requirements
- PhD in Immunology, Cancer Biology, Stem Cell Biology or a closely related discipline.
- Strong hands-on experience in mammalian cell culture and molecular biology techniques.
- Demonstrated ability to work independently, troubleshoot experiments and critically interpret scientific data.
- A strong track record of research productivity, with a clear motivation to publish high-quality scientific papers and advance an independent research career.
- Excellent communication, organisational and problem-solving skills.
Preferred Technical Expertise
Experience in one or more of the following areas will be advantageous:
- CRISPR-Cas9 gene editing and functional genomic screens.
- Patient-derived organoid culture and cancer models.
- Tumour immunology and immune functional assays.
- Peptide or antibody design and development.
- Animal experiments and in vivo cancer models.
- Bioinformatics and data analysis, particularly programming in R.
Req ID: 34961