Academic ConnectWork description:
The researcher will primarily study molecular mechanisms hypothesized to underly species adaptation by developing and using zebrafish models. Tasks include: 1) generating mutants using state of the art base editing and CRISPR/Cas9 approaches; 2) generating transgenic, fluorescent reporter lines for putative causal genes; 3) using in vivo fluorescence microscopy to visualize effects of variants; 4) preparing samples for downstream experiments and analyses, e.g. spatial and/or single cell RNA sequencing and other -omics approaches; 5) objectively quantifying image data; 6) data management, quality control, and statistical analysis of data; 7) staying up to date on methods development in the field and implementing important advances; 8) writing reports and presenting results to the team and at international meetings; and 9) disseminating results in manuscripts for publication in peer-reviewed journals.
Qualifications:
Applications are accepted from highly motivated candidates with a PhD in Molecular Biology or similar, with at least three years of relevant research experience at post-doctoral level.
Applicants must have a documented and broad competence in basic molecular biology methodology.
Documented experience with genome engineering in zebrafish is required.
Applicants must have at least 2 years of experience using zebrafish as a research animal.
Proficiency in micro-injections and zebrafish husbandry are required.
A successful candidate should be a highly motivated, organized, reliable team player who can also work independently.
Excellent communication in English is required, both orally and in writing.
Merits:
Prior knowledge and experience in fluorescence microscopy, data management, and image-based analyses are a bonus.
As part of the application, please describe your relevant research experience, knowledge, skills and personal abilities. In addition, we ask you to please describe what excites you about this position. Please also include a CV/resume; a list of publications in peer-reviewed journals.
About the employment
The employment is a permanent position, probationary period may be applied. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala
For further information about the position, please contact: Marcel den Hoed, marcel.den_hoed@igp.uu.se
Please submit your application by 15th August 2025, UFV-PA 2025/2072.
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