Job Information
Organisation/Company: Università di Pavia
Research Field: Biological sciences; Medical sciences
Researcher Profile: Recognised Researcher (R2); Leading Researcher (R4); First Stage Researcher (R1); Established Researcher (R3)
Application Deadline: 23 Sep 2026 - 12:00 (UTC)
Country: Italy
Type of Contract: To be defined
Job Status: Not Applicable
Is the job funded through the EU Research Framework Programme?: Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?: No
Offer Description
Pediatric Acute Lymphoblastic Leukemia is the most common childhood cancer (25–30% of the total) and B-cell Lymphoblastic Lymphoma is its related solid form. Both are treated with asparaginase, effective but associated with toxicities (allergies, pancreatitis) that may cause treatment discontinuation and worsen prognosis. Evidence indicates these effects might depend on the biological response to the drug. Asparaginase is degraded by proteases, particularly AEP and cathepsin B, often overexpressed in aggressive tumors. In high-risk cases, early loss of activity suggests increased degradation. We hypothesize that elevated proteases drive both toxicity and inefficacy. The project will: analyze AEP/CTSB in sera; characterize resulting peptides; test cytotoxicity on murine pancreas; develop strategies to reduce toxicity and restore efficacy.
Where to apply
Website: https://pica.cineca.it/unipv/tipologia/idr
Additional Information
Eligibility criteria
The public call with detailed attendance and selection rules (Art 4 and 6) can be found at: https://pica.cineca.it/unipv/tipologia/idr
The selections are open to candidates, Italian or foreigner, in possession, on the date of the deadline for submitting applications for the admission to the selection, of a master's degree or single-cycle, preferably in biological sciences, degree obtained no more than six years previously are eligible to participate in the selection process. These degrees must be relevant to the subject of the research activity.
Further specific assessable qualifications (see Art. 1 par. 1 Call for applications):
Proven previous experience in the field of research on mechanisms of resistance to anticancer treatments, alone or in combination, use of enzymatic drugs
Eligible destination country/ies for fellows:
- AFRICA
- EUROPE
- OCEANIA
- NORTH AMERICA
- SOUTH AMERICA
- ASIA
- OTHER
Eligibility of fellows: country/ies of residence:
- AFRICA
- EUROPE
- OCEANIA
- NORTH AMERICA
- SOUTH AMERICA
- ASIA
- OTHER
Eligibility of fellows: nationality/ies:
- AFRICA
- EUROPE
- OCEANIA
- NORTH AMERICA
- SOUTH AMERICA
- ASIA
- OTHER
Selection process
The application for admission to the selection procedure (dated and signed),the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page: https://pica.cineca.it/unipv/tipologia/idr selecting the Competition Notice you have chosen. In order to register with the system, you must have an email address. Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format. The selection of candidates is carried out on the basis of qualifications and possible interview (with test of knowledge of the foreign language) (see Art. 1 par. 1 Call for applications).
Website for additional job details: https://pica.cineca.it/unipv/tipologia/idr
Work Location(s)
Number of offers available: 1
Company/Institute: Università di Pavia
Country: Italy
Contact
City: Pavia
Website: https://portale.unipv.it/it