"Research Associate in Cellular Biochemistry or Biochemical Neuroscience"

Job summary

The Ye lab invites applications from talented, highly motivated, and ambitious postdoctoral scientists for a Research Associate position leading one or more projects exploring the role ofproteasomes in the clearance of toxic aggregates derived from pathological samples. The project will unveil factors that assist proteasomes in removing amyloidogenic proteins in healthy cells and the malfunction of proteasomes in pathological cells. You will use a multidisciplinary approach (protein extraction from donor tissues and established cell lines, fluorescence imaging and various cell biology techniques) to identify the types of modifications and potential factors that are associated with proteasomes during cell stress.

Please contact Dr Yu Ye – yu.ye1@imperial.ac.uk for a discussion about the project and role.

This role is part of the Department of Brain Sciences at Imperial College London, located in. Postdocs in the Ye lab at Imperial enjoy excellent career development opportunities with:

• Access to a range of cutting-edge technologies for 2D and 3D super-resolution imaging capabilities and dedicated iPSC culture facilities in the new state-of-the-art Sir Michael Uren Hub.
• A collegial, team-oriented working environment.
• National links with colleagues in the UK DRI and international links with colleagues at Harvard Medical School.
• Support from the Postdoc and Fellows Development Centre (PFDC) and Imperial and UK DRI ECR Communities
• The opportunity to mentor, supervise and teach students

Duties and responsibilities

As a Research Associate in the Ye lab, you will:

• Build on your existing skills and experience to address major components of this project independently.
• Present research findings as written reports, at conferences, within the College and as published manuscripts.
• Take initiative in the planning of research, with clear and timely communications to the Group Leader and relevant researchers.
• Contribute to the smooth running of the lab and facilities, acting collegiately with other scientists, clinicians, technicians and students.
• Provide guidance to staff and assist in the supervision of undergraduate and postgraduate research students, as required.
• Maintain highly organised and accurate records of experimental work.
• Undertake appropriate scientific and professional training.

Essential requirements

You are a motivated and organised researcher, excited by the science we do.

With (or near completion of) a PhD in cellular Biochemistry (or related discipline), you will be strongly objective-driven, able to lead the project independently and put new knowledge into practice effectively.

Experimental expertise working with molecular biology, protein biochemistry and cell culture is essential. Experience with IPS cell lines is a bonus.

Practical experience of advanced fluorescence microscopy, quantitative image analysis or coding research projects is highly desirable in the lab.