Rate My Professor Anupam Patgiri

The Patgiri Lab studies the mechanisms by which mutations in mitochondrial and metabolic genes cause neuromuscular disorders, with no current FDA-approved therapies available. Using small molecule and enzyme engineering, the lab aims to restore mitochondrial homeostasis and metabolic balance in cellular and animal disease models by correcting biochemical defects such as redox imbalances and bioenergetics, and selectively eliminating toxic mitochondria. Another research avenue explores modulating metabolism in the tumor-immune microenvironment to enhance cytotoxicity of T cells and macrophages as anticancer therapeutics. Patgiri's contributions to chemical biology and mitochondrial therapeutics are evidenced by over 3,200 citations on Google Scholar. Notable publications include 'Hepatic NADH reductive stress underlies common variation in metabolic traits' (Nature, 2020), 'Mitochondrial protein synthesis and the bioenergetic cost of neurodevelopment' (iScience, 2022), 'Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants' (Human Molecular Genetics, 2023), and 'Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration' (Molecular Biology of the Cell, 2025). His accolades include the Helen Hay Whitney Postdoctoral Fellowship (2013-2016), Tosteson & Fund Medical Discovery Fellowship (2017), and Keystone Symposia Future of Science Fund Scholarship (2020).