Encourages deep understanding and curiosity.
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Charles L. Sentman, PhD, serves as Professor of Microbiology and Immunology at Dartmouth College's Geisel School of Medicine and Director of the Center for Synthetic Immunity. He earned a PhD from the University of Texas Southwestern Medical Center and a BS from the University of Illinois. His postdoctoral training included research at Washington University Medical School in St. Louis on the role of cell death in T cell development and at the Microbiology and Tumor Biology Center at the Karolinska Institute in Stockholm on natural killer (NK) cell recognition mechanisms. In 1997, he received a docentur in molecular immunology from Umea University. Sentman joined the medical faculty at Umea Center for Molecular Pathogenesis in 1995, served as team and section leader at AstraZeneca R&D in Lund, Sweden from 1998 to 2001 focusing on pharmaceuticals for respiratory and inflammatory diseases, and joined Dartmouth's Department of Microbiology and Immunology in 2001. He is a member of the Immunology and Cancer Immunotherapy Research Program at the Dartmouth Cancer Center.
Sentman's research centers on innate immunity, NK cells, CD8 T cells, and their regulation of adaptive immunity against cancer and infection. Since 2003, his laboratory has pioneered chimeric antigen receptor (CAR) therapies, developing NKG2D-based CARs targeting tumors expressing ligands like those on ovarian cancer, lymphoma, myeloma, breast cancer, melanoma, and osteosarcoma. Additional efforts include bi-specific T cell engagers against tumor ligands such as MICA, B7H6, and ULBPs, and CAR Tregs for neurodegenerative diseases including Alzheimer's, ALS, and Parkinson's. Key publications encompass 'NKG2D CAR T cell therapy inhibits the growth of antigen heterogeneous tumors' (2013), 'Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma' (2019), 'Human CAR Tregs Targeting SOD1 and Expressing BDNF Reduce Inflammation and Delay Disease in G93A hSOD1-NSG Mice' (2025), and '5xFAD-NSG mice: a preclinical Alzheimer model for human cell therapy studies' (2026). With over 100 peer-reviewed publications and more than 30 issued US patents, Sentman co-founded Oncyte, acquired by Celyad in 2015, and Black Bear Bio, advancing therapies toward clinical development in collaboration with Celdara Medical and Dartmouth-Hitchcock Medical Center. In 2022, he was named a Fellow of the National Academy of Inventors for his innovations in immune cell engineering.

Photo by Osarugue Igbinoba on Unsplash
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