Rate My Professor Cynthia Dupureur

Her research focuses on the structure and function of metallonucleases and restriction endonucleases, particularly the roles of divalent metal ions in DNA binding and catalysis. She employs techniques such as enzyme kinetics, isothermal titration calorimetry, fluorescence spectroscopy, and multidimensional NMR spectroscopy. Dupureur has published extensively, with key works including "Roles of metal ions in nucleases" (Current Opinion in Chemical Biology, 2008), "Effects of divalent metal ions on the activity and conformation of the N- and C-terminal fragments of PvuII" (Biochemistry, 1999), "A catalytically deficient active site variant of PvuII endonuclease functions as a specific nickase" (Journal of Biological Chemistry, 2000), "NMR studies of restriction enzyme-DNA interactions" (Biochemistry, 2005), and "Improved Antiviral Activity of a Polyamide Against High-Risk Human Papillomavirus" (Bioorganic & Medicinal Chemistry Letters, 2016). By 2001, she had authored 22 peer-reviewed articles and obtained over $650,000 in external funding. She presented the department's history at its 60th anniversary celebration in 2024 and actively participated in alumni events during her chair tenure.