Rate My Professor Daniel Panne

Professor Daniel Panne serves as Professor in Structural Biology in the Department of Molecular and Cell Biology at the University of Leicester. His research specializes in the structural biology of signal transduction and epigenetic gene regulation, exploring how signalling pathways control gene expression by epigenetic modulation of chromatin structure. Key areas include the innate immune system and pattern recognition receptors; the interplay between cellular signalling, transcription factor activation, and coassembly on transcriptional enhancers; higher-order transcription factor complexes such as enhanceosomes; recruitment of co-activators CBP/p300; chromatin acetylation; nucleosome remodelling; genome regulation; architecture of signalling complexes; assembly of transcriptional regulatory complexes; chromatin modification; and contributions of components regulating higher-order chromatin structure to genome regulation. Panne's laboratory employs biophysical techniques such as X-ray crystallography, cryo-electron microscopy, crosslinking, and native mass spectrometry.

Daniel Panne's influential publications encompass Buenaventura T et al., Competition shapes the landscape of X-chromosome-linked genetic diversity, Nature Genetics (2024); García-Nieto A et al., Structural basis of centromeric cohesion protection, Nature Structural & Molecular Biology (2023); Ibrahim Z et al., Structural insights into p300 regulation and acetylation-dependent genome organisation, Nature Communications (2022); Li Y et al., The structural basis for cohesin-CTCF anchored loops, Nature (2020); Muir KW et al., The structure of the cohesin ATPase elucidates the mechanism of SMC-kleisin ring opening, Nature Structural & Molecular Biology (2020); Ortega S et al., Cellular signalling activates the p300 acetyltransferase through transcription factor dimerization, Nature (2018); Sauer P et al., Insights into the molecular architecture and histone H3-H4 deposition mechanism of the Chromatin assembly factor 1, eLife (2017). He leads major funded initiatives, including a multi-million pound study on chromosome biology mysteries and Wellcome Trust Investigator Awards in collaboration with colleagues at the Leicester Institute for Structural and Chemical Biology. Previously, Panne held a position as Research Assistant at Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, from July 2000 to August 2007.