Rate My Professor David Tremethick

Professor David Tremethick serves as Professor at the John Curtin School of Medical Research (JCSMR), The Australian National University (ANU), since 2008, and as Head of the Genome Biology Department there since 2010. A graduate of the University of Sydney with a BSc (Hons) and Macquarie University with a PhD, he conducted postdoctoral research at the Department of Biology, University of Rochester, United States, from 1990 to 1992. In 1992, he joined JCSMR at ANU as Research Fellow and Group Leader (1992-1996), followed by Fellow (1997-1999), Fellow (1999-2002), Senior Fellow (2003-2007), leading to his current professorial role. He is also a Member of the Division of Genome Sciences and Cancer and the Shine-Dalgarno Centre for RNA Innovation.

Internationally recognized leader in the field of chromatin biology, Professor Tremethick leads The Tremethick Group - Chromatin and Transcriptional Regulation during Development. The group's research elucidates the epigenome's functions, with a particular emphasis on histone variants H2A.Z and H2A.B, in controlling gene transcription, pre-mRNA splicing, chromatin compaction and architecture, and three-dimensional genome organization. These processes are studied in the contexts of embryonic development, stem cell differentiation, and disease pathogenesis, including breast cancer progression, Hodgkin lymphoma, brain function, and male fertility. Advanced methodologies employed include sequential chromatin immunoprecipitation, long-range chromatin interaction mapping, and computational modeling of genome folding in human stem cells. Professor Tremethick's impactful contributions are documented in high-profile publications such as "Multifunctional histone variants in genome function" (2025), "The Role of the Histone Variant H2A.Z in Metazoan Development" (2022, Journal of Developmental Biology), "H2A.B is a cancer/testis factor involved in the activation of ribosome biogenesis in Hodgkin lymphoma" (2021, EMBO Reports), "Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells" (2021, Nature Communications), and "Long-range interactions between topologically associating domains shape chromatin architecture in mouse spermatogonial stem cells" (2019). Additionally, he has obtained the NHMRC 2023 Equipment Grant - AKTA Go FPLC System (2023–2024).