Rate My Professor Dean Wiseman

Dean Wiseman is an Associate Professor of Biology at the University of Indianapolis. He earned his PhD and MS in Biological Science from Purdue University, and a BA in Biology from DePauw University. Prior to his current position, Wiseman served as a Research Assistant Professor at Indiana University School of Medicine, where he studied the underlying causes of Type 2 diabetes. There, he contributed to the discovery of multiple proteins in pancreatic insulin-secreting beta cells that become modified upon stimulation with glucose, thereby indicating their critical role in the insulin release process. These proteins are particularly noteworthy because the specific modifications may render them susceptible to stress, potentially leading to dysfunctional cellular activity and diabetes. This research was documented in publications such as the Journal of Biological Chemistry (2011 May 6; 286(18):16344-54) and Current Diabetes Reviews (2012 Jul 1;8(4):303-15).

Wiseman's expertise spans physiology, cell biology, pathophysiology, and pharmacology. His research interests center on the involvement of protein post-translational modifications in the pathogenesis of diabetes and cancer, alongside investigations into cave environments concerning water quality, antibiotic-resistant bacteria, and endemic cave fauna. Key publications include 'Stimulus-induced S-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis' (Journal of Biological Chemistry, 2011), 'Gelsolin Associates with the N Terminus of Syntaxin 4 to Regulate Insulin Granule Exocytosis' (Traffic, 2011), 'The Good and Bad Effects of Cysteine S-nitrosylation and Tyrosine Nitration upon Insulin Exocytosis: A Balancing Act' (Current Diabetes Reviews, 2012), and 'Evaluation of Antimicrobial Resistance to Broad-Spectrum Antibiotics in Fluvent Cave Soils, Lawrence County, Indiana' (2016). His scholarly output, focused on mechanisms of insulin exocytosis, oxidative stress, nitric oxide signaling, and endothelial cell function, has been cited over 1,200 times according to Google Scholar, underscoring his contributions to cellular physiology and disease-related protein dynamics.