Rate My Professor Greg Miller

Greg J. Miller, Ph.D., serves as Chair and Associate Professor of Biochemistry in the Department of Chemistry at The Catholic University of America, part of the College of Arts and Sciences in Washington, D.C. He earned a B.S. in Biochemistry and a Ph.D. from The University of Western Ontario. Prior to his appointment at CUA, Miller was an Assistant Professor at McGill University and conducted postdoctoral research at the National Institutes of Health. In his role as department chair, he leads faculty, research efforts, and educational programs in chemistry and biochemistry.

Miller's research centers on protein structure and function, cellular signaling, enzymology, and molecular biology, with a specific focus on kinases and phosphatases that generate soluble inositol phosphate (IP) and membrane-bound phosphatidylinositol (PI) signals in human cells. Dysregulation of these ubiquitous signaling pathways is associated with various disease states. His laboratory employs X-ray crystallography to determine high-resolution structures of these enzymes, protein engineering to correlate structure with catalytic function and downstream effects, and proteomics to map cellular protein interactions. These integrated approaches provide insights into enzyme specificity, regulation, and potential for inhibitor design targeting inositol-based networks. Prominent publications include 'Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase' (Molecular Cell, 2004), 'Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase' (Molecular Cell, 2005), 'Recognizing phosphatidylinositol 3-phosphate' (Cell, 2001), and 'The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action' (Pharmacological Reviews, 2013). He is currently editing Methods in Molecular Biology: Inositol Phosphates. Miller's contributions have significantly influenced structural biology and phosphoinositide signaling research, as evidenced by extensive citations of his work. He also serves on the ASBMB Science Outreach and Communication Committee, promoting public engagement with science.