Rate My Professor James Stone

James R. Stone, MD, PhD, is Vice Chairman of Clinical Research and Professor of Radiology and Medical Imaging at the University of Virginia Department of Radiology and Medical Imaging. He received his BS in Biology from Virginia Commonwealth University in 1995, PhD in Anatomy and Neurobiology from the Medical College of Virginia (Virginia Commonwealth University) in 2000, and MD from the University of Virginia School of Medicine in 2004. His training includes a research fellowship in the Department of Anatomy and Neurobiology at Virginia Commonwealth University School of Medicine in 2000, an internship in General Surgery at the University of Virginia School of Medicine in 2005, residency in the Interventional Radiology Clinical Pathway in the Department of Radiology at the University of Virginia from 2005 to 2009, and a clinical fellowship in the Division of Interventional Radiology at the University of Virginia in 2010. Stone is board-certified by the American Board of Radiology in Interventional Radiology and Diagnostic Radiology.

Dr. Stone's research focuses on traumatic brain injury (TBI) sustained in modern military conflicts, developing novel molecular imaging probes to improve clinical diagnosis of acute and chronic effects, ultrasound-based detection approaches for far-forward environments, neurovascular changes from blast overpressure, and neuroimaging correlates of repetitive low-level blast exposure as an occupational hazard. His investigations, supported by agencies including CDMRP/DHP, MRMC, DARPA, BUMED, and GE, have led to significant grants such as $3.2 million from the Department of Defense in 2025 to expand brain health protection tools for military personnel, $2.3 million to test MRI for undetected brain injuries, and $5.3 million for neurovascular unit studies in brain injury prevention. Stone collaborates with the U.S. Navy, NIH, and Department of Defense, serves as principal investigator on clinical trials, directs a national imaging core laboratory, and was appointed by NATO to develop guidelines for preventing chronic neurological changes from blast exposure. He received the 2024 Distinguished Investigator Award from the Academy for Radiology and Biomedical Imaging Research, Resident Research Awards from the UVA Department of Radiology (2007-2009), and was co-author of the Clinical Abstract of the Year at the Society of Interventional Radiology's 41st Annual Meeting (2015). Key publications include "Neurological Effects of Repeated Blast Exposure in Special Operations Personnel" (2024), "Assessment of the Effects of Acute and Repeated Exposure to Blast Overpressure in Rodents" (2012), "Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury" (2004), and "Caspase-3 mediated cleavage of the amyloid precursor protein and formation of the amyloid beta peptide in traumatic axonal injury" (2002).