Rate My Professor Kristine Doyle

Kristian Doyle is a Professor of Immunobiology and Neurology at The University of Arizona, with additional appointments in the Arizona Center on Aging, BIO5 Institute, Neurosurgery, Neuroscience Graduate Interdisciplinary Program, and Psychology. He earned a PhD in Immunology from Oregon Health & Science University in 2007, where he developed novel therapeutics for stroke in the laboratory of Dr. Mary Stenzel-Poore, and a BS in Biology from the University of Sussex in 2000. After postdoctoral training as a Research Associate at Stanford University from 2008 to 2013 under Dr. Marion Buckwalter, investigating TGFβ signaling after stroke and developing a model of post-stroke dementia, he joined The University of Arizona as Assistant Professor in 2013 and was promoted to Associate Professor in 2019. Earlier, he served as a Postdoctoral Fellow at Virogenomics, developing primate stroke models.

Dr. Doyle's research centers on the immune system's role in stroke recovery, demonstrating that chronic inflammation, driven by myelin debris processing and foam cell formation, causes sustained cell death surrounding stroke lesions for months, impairing cognition. His Doyle Lab targets these processes to promote repair and functional outcomes. Landmark publications include "Mechanisms of ischemic brain damage" (Neuropharmacology, 2008), cited over 1,350 times; "B-lymphocyte-mediated delayed cognitive impairment following stroke" (Journal of Neuroscience, 2015); and "Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts" (Neurobiology of Disease, 2018). With over 4,350 citations, his work has secured NIH funding as principal investigator, including R01 grants on stroke-Alzheimer's interactions and a K99/R00 pathway award from the National Institute of Nursing Research in 2012. Awards encompass the American Federation of Aging Research Fellowship (2009) and Anita Roberts Young Scientist Scholarship (2010). A founding member of the international Stroke-IMPaCT network, he reviews for journals like Neurobiology of Disease and NIH panels, mentoring students and postdocs.