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About Malcolm
Professor Malcolm Logan serves as Professor of Regenerative Biology in the Randall Centre for Cell and Molecular Biophysics within the Faculty of Life Sciences & Medicine at King’s College London. He holds a BSc and PhD. His laboratory examines the mechanisms governing vertebrate limb development and the origins of limb-affecting diseases. This work integrates animal models with human tissue analyses to investigate early signals that recruit limb bud progenitors and subsequent morphogenesis events that pattern these progenitors into functional limb structures, with particular emphasis on muscle and bone formation. The group elucidates how disruptions in these processes contribute to congenital limb malformations such as radial dysplasia and pathologies of the musculoskeletal system. Additionally, the research explores regenerative approaches informed by developmental principles to address congenital defects, trauma-induced damage, and age-related degeneration. Logan leads the Logan Group, focusing on limb formation, homeostasis, and disease disruptions, and supervises PhD students including George Murphy and Sarah Brown.
Logan has produced 58 research outputs, garnering 3642 citations. Notable publications encompass 'Abnormal extracellular matrix deposition by fascial fibroblasts underlies the connective tissue pathology in the disease Radial Dysplasia' (Matrix Biology, 2026), 'Soft tissue abnormalities in the congenital limb malformation radial dysplasia (RD): Their clinical impact and treatment significance' (Journal of Anatomy, 2026), 'Investigating the role connective tissue fibroblasts play in the altered muscle anatomy associated with the limb abnormality, Radial Dysplasia' (Journal of Anatomy, 2024), 'Molecular Function and Contribution of TBX4 in Development and Disease' (American Journal of Respiratory and Critical Care Medicine, 2023), 'The Prrx1eGFP Mouse Labels the Periosteum During Development and a Subpopulation of Osteogenic Periosteal Cells in the Adult' (JBMR Plus, 2023), and '4D formation of human embryonic forelimb musculature' (Development, 2021). He is principal investigator on grants including the BBSRC-funded 'Manipulating a morphogen in space and time' (2026-2029, with co-investigator Anthony Graham), MRC projects 'Improving diagnosis and treatment of congenital muscle abnormalities by understanding the activities of irregular connective tissue fibroblasts' (2023-2026) and 'Understanding the activities of connective tissue fibroblasts during muscle formation towards understanding disease and engineering muscle tissue' (2018-2021), and the BASK pump-priming award 'Identifying the Causes of ACL Graft Failures' (2026-2028). Logan serves on the editorial board of Developmental Biology and collaborates with clinical departments in genetics, plastics, and orthopaedics.
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