Rate My Professor Mette Goodin

Dr. Mette Goodin holds an MSc and PhD from the University of Otago. Her research career began in the Department of Pharmacology and Toxicology at the University of Otago, where she conducted studies on the toxicological effects of polyphenolic compounds found in green tea and other natural sources. Her work focused on how these compounds modulate drug-metabolizing enzymes and impact physiological processes. Key publications include 'Epigallocatechin Gallate Modulates CYP450 Isoforms in the Female Swiss-Webster Mouse' published in Toxicological Sciences in 2003, co-authored with Rhonda J. Rosengren; 'Curcumin modulates drug metabolizing enzymes in the female Swiss-Webster mouse' in Life Sciences in 2006, also with Rosengren; and 'Renal PGE2 production in the human and rat following phenacetin administration' in 2003, with Robert J. Walker and Rosengren. Additional research explored green tea polyphenols' inhibition of testosterone production in rat Leydig cells, the combination of epigallocatechin gallate and curcumin suppressing ER alpha-breast cancer cell growth, and safety studies on epigallocatechin gallate preparations including teratogenicity and reproductive toxicity in rats. These studies, totaling six publications affiliated with the University of Otago, contributed to knowledge on biotransformation enzyme modulation, antioxidant effects, and potential health implications of dietary polyphenols.