Rate My Professor Miriam Rademaker

Associate Professor Miriam T. Rademaker is a Research Associate Professor in the Department of Medicine, University of Otago Christchurch, and Co-Director of the Physiology Division at the Christchurch Heart Institute. She earned her BSc from the University of Canterbury and PhD from the University of Otago. Her research investigates the integrated cardiovascular, endocrine, and renal control of pressure and volume homeostasis, emphasizing vasoactive hormones including natriuretic peptides, adrenomedullins, endothelin, and the renin-angiotensin-aldosterone system in the pathophysiology of hypertension, myocardial infarction, and heart failure. Recent interests encompass the urocortin family of peptides, phosphodiesterase 9 inhibition, natriuretic peptide analogues with targeted vasodilatory or renal effects, renal dysfunction in heart failure, and novel implantable devices for detecting early heart failure decompensation.

Rademaker has made substantial contributions to cardioendocrinology through preclinical ovine models of heart failure, authoring over 120 publications cited more than 2,900 times. Notable works include "Combined inhibition of phosphodiesterases-5 and -9 in experimental heart failure" (JACC: Heart Failure, 2024), "Phosphodiesterase 9 inhibition combined with valsartan and with sacubitril/valsartan in experimental ovine heart failure" (Journal of the American Heart Association, 2024), and "Haemodynamic, hormonal and renal actions of osteocrin in normal sheep" (Experimental Physiology, 2024). She has secured Heart Foundation of New Zealand project grants, such as $154,802 in 2020 for phosphodiesterase-9 inhibition versus/plus neprilysin inhibition in experimental heart failure, and $152,100 in 2017 for phosphodiesterase 9 inhibition in heart failure. Additionally, she is a member of the Christchurch School of Medicine Faculty and the Canterbury Medical Research Society, and serves on the editorial boards of the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology and Clinical Science.