Rate My Professor Mohammad Nazim

Mohammad Nazim, PhD, is an Assistant Professor in the Department of Biochemistry at the School of Medicine, Case Western Reserve University, and a member of the Center for RNA Science and Therapeutics. He received his B.S. and M.S. in Biochemistry and Molecular Biology from the University of Dhaka, Bangladesh. Nazim obtained his Ph.D. from the Graduate School of Medicine, Nagoya University, focusing on neurogenetics, including competitive regulation of alternative splicing and alternative polyadenylation in the acetylcholinesterase transcript and splicing mutations in neuromuscular disorders. He then completed postdoctoral research at the David Geffen School of Medicine, University of California, Los Angeles, in the laboratory of Douglas L. Black.

The Nazim Lab defines the mechanistic interface between post-transcriptional RNA regulation and chromatin regulation that governs transcriptional and epigenetic programs in stem cell maintenance, cellular differentiation, tissue development, and disease. Research examines how alternative RNA splicing shapes these programs in embryonic stem cells and neuronal differentiation, the distinct functions of splice variants of chromatin regulators in lineage-specific differentiation, and how splicing defects contribute to neurodevelopmental disorders and cancer. The lab utilizes cell culture systems, genetically engineered mouse models, and genomic technologies. Nazim's publications include "Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation" in Cell Stem Cell (2024), "Post-transcriptional regulation of the transcriptional apparatus in neuronal development" in Frontiers in Molecular Neuroscience (2024), "Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms" in Nucleic Acids Research (2017), and several on splicing regulation in congenital myasthenic syndromes.