Rate My Professor Nick Powell

Powell’s research centres on the molecular and cellular mechanisms driving chronic intestinal inflammation, with a focus on inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis, and gut inflammation induced by cancer immunotherapies like immune checkpoint inhibitors. His work explores cytokine-responsive transcriptional networks, host-microbe interactions via the gut microbiota and metabolome, and molecular signatures to advance precision medicine for predicting disease outcomes and therapy responses. He has obtained substantial funding, including a Wellcome Trust Senior Clinical Research Fellowship exceeding £3 million over eight years, alongside awards from the Medical Research Council, NIHR, Crohn’s and Colitis UK, and the Leona M. and Harry B. Helmsley Charitable Trust. Powell chaired the British Society of Gastroenterology guidance on immune checkpoint inhibitor colitis management, serves as Deputy Chair of the BSG IBD Clinical Research Group, and sits on the European Crohn’s and Colitis Organisation Scientific Committee. Key publications include Lo JW et al., 'Immune checkpoint inhibitor-induced colitis is mediated by polyfunctional lymphocytes and is dependent on an IL23/IFNγ axis' (Nature Communications, 2023); Liu Z et al., 'Infliximab and Tofacitinib Attenuate Neutralizing Antibody Responses Against SARS-CoV-2' (Gastroenterology, 2023); and Powell N et al., Immunity (2012).