Rate My Professor Paul Costantino

Costantino's research centers on Staphylococcus aureus, with emphasis on biofilms, virulence factors, antibiotic resistance, and vaccine development for bovine mastitis prevention. His investigations utilize non-invasive mouse mastitis models to assess immunogenicity and protective efficacy of biofilm versus planktonic vaccines. Key publications include 'Mammary Gland Pathology Subsequent to Acute Infection with Strong versus Weak Biofilm Forming Staphylococcus aureus Bovine Mastitis Isolates: A Pilot Study Using Non-Invasive Mouse Mastitis Model' (2017, PLOS One); 'In Vitro Antimicrobial Efficacy of Tobramycin Against Staphylococcus aureus Biofilms in Combination With or Without DNase-I and/or DispersinB: A Preliminary Investigation' (2016, Microbial Drug Resistance); 'Diversity of Virulence Factors Associated with West Australian Methicillin-Sensitive Staphylococcus aureus Isolates' (2016, Journal of Pathogens); 'Relative Distribution of Virulence-Associated Factors Among Australian Bovine Staphylococcus aureus Isolates: Potential Relevance to Development of an Effective Bovine Mastitis Vaccine' (2015, Virulence); 'Intramammary Immunization of Pregnant Mice with Staphylococcal Aures Surface-Associated Immunogens: A Model for Perinatal Passive Protection of Neonates Against Bovine Mastitis Pathogens' (2016, PLOS One); 'Serological Versus Molecular Typing of Surface-Associated Immune Precipitinogens of Australian Staphylococcus aureus Isolates' (2014, Journal of Medical Microbiology); and 'Human Methicillin-Sensitive Staphylococcus aureus Biofilms are More Susceptible to Tobramycin When Grown in the Presence of DNase-I and Dispersin B' (2013, Journal of Basic Microbiology). These works, often in collaboration with researchers at Curtin Health Innovation Research Institute, including Trilochan Mukkur and Jully Gogoi-Tiwari, contribute to advancements in understanding S. aureus pathogenesis and therapeutic strategies.