Rate My Professor Philip Eaton

Professor Philip Eaton is Professor of Cardiovascular Biochemistry in the Faculty of Medicine and Dentistry at Queen Mary University of London, where he is based at the William Harvey Research Institute in the Centre for Clinical Pharmacology and Precision Medicine. He obtained a BSc in Biochemistry from Queen Mary College, University of London in 1989 and completed his PhD at the University of Sussex. Following postdoctoral research at the Institute of Psychiatry, Eaton joined the Department of Cardiovascular Research at the Rayne Institute, St Thomas’ Hospital in 1995. He spent nearly 24 years at King’s College London within the School of Cardiovascular Medicine & Sciences before moving to the William Harvey Research Institute in 2019 to head a research group focused on the molecular basis of redox sensing and signalling in the cardiovascular system.

Eaton’s research examines how oxidants function as regulatory signals by reacting with select cysteine thiol side chains on proteins, leading to oxidative post-translational modifications that alter protein function for adaptation and homeostasis during cardiovascular health and disease. His team identifies thiol-based redox sensor proteins and develops electrophilic drugs that target precise redox-regulated cysteines for therapeutic benefit against cardiovascular conditions. In 2023, he was awarded a €2.5 million European Research Council Advanced Grant. Eaton has published extensively in high-impact journals, including “Cysteine Redox Sensor in PKGIα Enables Oxidant-Induced Activation” (Science, 2007), “Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability To Cause Aortopathy” (JACC: Basic to Translational Science, 2026), “A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective” (Redox Biology, 2025), and “Protein kinase GIα oxidation negatively regulates antibody production by B cells” (Redox Biology, 2025). He contributes to teaching as an MBBS SSC supervisor, BHF MRes lecturer, and PhD supervisor and examiner, influencing the next generation of cardiovascular researchers.