Rate My Professor Sam Jamieson

Jamieson's research specializes in the structural biology of pseudokinases, membrane transporters, and ubiquitin-related complexes, employing X-ray crystallography and cryo-electron microscopy. He is first author on several influential papers, including 'Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1' (Science Signaling, 2018; 75 citations), which reveals the activation mechanism of TRIB1 relevant to cancer signaling, and 'Nanobodies identify an activated state of the TRIB2 pseudokinase' (Structure, 2022; 11 citations). Other key publications co-authored by Jamieson encompass 'Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase' (Structure, 2015; 134 citations), 'Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1' (PNAS, 2017; 52 citations), 'Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter' (Nature Communications, 2023; 25 citations), 'Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus' (ACS Infectious Diseases, 2020; 22 citations), 'DET1 dynamics underlie cooperative ubiquitination by CRL4DET1-COP1 complexes' (Science Advances, 2025; 4 citations), and 'Structural basis of isethionate transport by a TRAP transporter from a sulfate-reducing bacterium' (Structure, 2026). Jamieson has received Research Support awards from the Faculty of Biomedical Sciences, recognizing his outstanding contributions to research infrastructure and collaboration.