Rate My Professor Sergi Garcia-Manyes

Garcia-Manyes’ research specializes in single-molecule mechanobiology, exploring conformational dynamics of proteins under mechanical force, mechanochemical reactions at the single-bond level, and nanomechanics of cellular membranes and lipid bilayers using atomic force microscopy and force-clamp spectroscopy. His laboratory investigates how mechanical forces regulate protein folding, nuclear translocation, cell-cell junctions, and ribosome-mediated membrane protein folding. Key publications include “Structural anisotropy results in mechano-directional transport of proteins across nuclear pores” (Nature Physics, 2024), “Single-molecule magnetic tweezers to probe the equilibrium dynamics of individual proteins at physiologically relevant forces and timescales” (Nature Protocols, 2024), “Force-Triggered Thermodynamically Uphill Disulfide Reduction through Sulfur Oxidation State Control” (Journal of the American Chemical Society, 2025), “The role of single protein elasticity in mechanobiology” (Nature Reviews Materials, 2023), and “Allosteric activation of vinculin by talin” (Nature Communications, 2023), amassing over 4,700 citations. He has secured major awards such as the EPSRC Early Career Fellowship (2012), Leverhulme Research Leadership Award, Wellcome Trust Investigator Award, Royal Society Wolfson Fellowship, 2012 Spanish Biophysical Society award, and funding from three Marie Curie Actions, BBSRC, Royal Society, British Heart Foundation, and Fight for Sight.