Rate My Professor Simon Pieraut

Dr. Pieraut’s research program centers on the molecular and cellular mechanisms driving neural plasticity, particularly how experiences induce changes in neural network connectivity through the remodeling of inhibitory synapses. His work focuses on cholecystokinin (CCK)-expressing basket cells in the dentate gyrus, utilizing sophisticated methods such as mouse genetics, viral gene delivery, optogenetics, and in vivo calcium imaging. These studies aim to uncover pathways essential for adaptive plasticity and their dysfunction in neurodevelopmental and psychiatric disorders. Notable publications include “The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation” in Neuron (2013, 437 citations), “HDAC4 governs a transcriptional program essential for synaptic plasticity and memory” in Cell (2012, 314 citations), “SNAREs controlling vesicular release of BDNF and development of callosal axons” in Cell Reports (2015, 136 citations), and “Experience-dependent remodeling of basket cell networks in the dentate gyrus” in Neuron (2014, 48 citations). With over 1,500 citations on Google Scholar, his contributions have significantly influenced the field of neuroscience. Recently, the Pieraut Neuro Lab secured an $800,000 five-year grant from the National Science Foundation to investigate CCK inhibitory neuron plasticity in hippocampal function. In teaching, Dr. Pieraut emphasizes critical thinking in neuroscience, bridging foundational concepts with cutting-edge research to prepare students for diverse STEM careers.