Helps students see the bigger picture.
Helps students see the bigger picture.
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William Mayhan, Ph.D., serves as Dean of Biomedical Sciences in the Sanford School of Medicine at the University of South Dakota. He earned his Ph.D. from the University of Nebraska Medical Center in 1983, a B.S. in Biology from Creighton University in 1977, and completed a Postdoctoral Fellowship at the University of Iowa in 1985. Prior to joining USD, Mayhan was a Professor in the Department of Cellular Biology and Anatomy at Louisiana State University Health Sciences Center Shreveport. His research is centered on examining endothelial cell function in the cerebral microcirculation, specifically regulation of vascular function and permeability of the blood-brain barrier. He investigates changes in cerebral blood vessels during disease states such as type 1 diabetes, hypertension, chronic alcohol consumption, nicotine exposure, and prenatal alcohol exposure. These studies provide insight into the pathogenesis of stroke and ischemic brain injury.
Mayhan's specialty is Cerebral Microcirculation & Vascular Biology, and his teaching interests include Cardiovascular Physiology. He has authored over 224 peer-reviewed publications, cited more than 8,974 times. Notable publications include "Tetrahydrobiopterin rescues impaired responses of cerebral resistance arterioles during type 1 diabetes" (Diabetes & Vascular Disease Research, 2017), "Prenatal exposure to alcohol: mechanisms of cerebral vascular damage and lifelong consequences" (Alcohol, 2022), "Rosiglitazone restores nitric oxide synthase-dependent reactivity of cerebral arterioles in rats exposed to prenatal alcohol" (2021), "Influence of type 1 diabetes on basal and agonist-induced permeability of the blood-brain barrier" (Physiological Reports, 2015), "Vigorous exercise training improves reactivity of cerebral arterioles and reduces brain injury following transient focal ischemia" (Microcirculation, 2014), "Influence of exercise training on ischemic brain injury in type 1 diabetic rats" (Journal of Applied Physiology, 2012), and "Low-dose alcohol consumption protects against transient focal cerebral ischemia in mice: possible role of PPARγ" (PLoS ONE, 2012). His work has advanced understanding of cerebrovascular dysfunction in pathological conditions.
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