Rate My Professor Xinglong Wang

Xinglong Wang is the R. Ken and Donna Coit Endowed Chair in Aging and Neurodegenerative Diseases and Professor in the Department of Pharmacology and Toxicology at the R. Ken Coit College of Pharmacy, University of Arizona. He earned his Ph.D. in Pathology from Case Western Reserve University in Cleveland in 2009. Before joining the University of Arizona in 2022, Wang held positions as Assistant Professor from 2013 to 2018 and Associate Professor in the Department of Pathology at Case Western Reserve University School of Medicine.

Wang's research centers on the mechanisms underlying neuronal death in major neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis. His investigations highlight mitochondrial dysfunction, TDP-43 proteinopathies, liquid-liquid phase separation, protein aggregation, and oxidative stress as critical pathological features. Key contributions include elucidating mitochondrial defects and oxidative stress in Alzheimer’s disease, abnormal mitochondrial dynamics in neurodegenerative diseases, and TDP-43 proteinopathy with mitochondrial abnormalities. Recent publications encompass 'The mechanisms underlying TDP-43-associated neurodegeneration in Alzheimer’s disease and related dementias' (Molecular Psychiatry, 2025), 'Standardization and consensus in the development and application of bone organoids' (Theranostics, 2025), 'Protein co-aggregates of dense core amyloid plaques and CSF differ in rapidly progressive Alzheimer’s disease and slower sporadic Alzheimer’s disease' (Alzheimer's Research and Therapy, 2025), 'Association of Polygenic Risk Score for 5 Diseases with Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition' (Neurology, 2025), and 'Aggregatin is a mitochondrial regulator of MAVS activation to drive innate immunity' (Journal of Immunology, 2025). Earlier works include 'Mitochondrial defects and oxidative stress in Alzheimer disease,' 'Abnormal mitochondrial dynamics and neurodegenerative diseases,' and 'Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease.' Wang received a Flinn Foundation Seed Grant in 2023 for health care innovations. He has presented on mitochondria in neurodegenerative diseases from pathology to therapeutics and directs a lab studying TDP-43 neurotoxicity and mitochondrial pathology.