Rate My Professor Yuh-Cherng Chai

Yuh-Cherng Chai, Ph.D., is Professor and Chair of the Department of Chemistry & Biochemistry in the College of Arts & Sciences at John Carroll University. He earned his B.S. and Ph.D. from Iowa State University. Dr. Chai joined the John Carroll University faculty in the fall of 2002 as a Visiting Assistant Professor and has advanced to his current tenured position as Professor. Prior to joining John Carroll University, he conducted independent research at the Lerner Research Institute of The Cleveland Clinic Foundation, where he mentored three undergraduate students from John Carroll University. Earlier in his career, he served as a member of the Cleveland Clinic teaching faculty, lecturing in biochemistry at Cleveland State University from 1994 to 1998 and participating in radiobiology lectures for Radiation Oncology residents. Dr. Chai teaches General Chemistry, Biochemistry, and Biochemistry Laboratory courses at John Carroll University.

Dr. Chai's research investigates the cellular and biochemical mechanisms underlying human diseases induced by oxidant stress, with a particular emphasis on protein S-glutathionylation, glutathione, glutaredoxin, and their roles in cellular redox homeostasis and signaling. His notable publications include the review article 'Glutathione and Glutaredoxin—Key Players in Cellular Redox Homeostasis and Signaling' (Antioxidants, 2023, co-authored with John J. Mieyal), 'Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease' (International Journal of Molecular Sciences, 2020, co-authored with Aysenur Musaogullari), and 'The Effect of Oxidant and the Non-Oxidant Alteration of Cellular Thiol Concentration on the Formation of Protein Mixed-Disulfides in HEK 293 Cells' (Chemistry, 2008, co-authored with Jasen L. Gilge and Michael Fisher). He has authored or co-authored 16 research articles and one book chapter. Dr. Chai received the Tarazi Prize for significant achievement in cardiovascular research at the Cleveland Clinic Foundation and was funded by the American Heart Association Northeast Ohio Chapter from 1995 to 1997. His work has garnered approximately 398 citations.