Advanced Lasers for Quantum Enhanced Microscopy

About the Project

Supervisors:

Dr. Lin Xu l.xu@soton.ac.uk

Prof. Sumeet Mahajan

This project, within the EPSRC Centre for Doctoral Training in Quantum Technology Engineering at the University of Southampton (https://qte.ac.uk), carries a UKRI TechExpert enhanced annual stipend around £31k for UK students. While researching the project outlined below you will also receive substantial training in scientific, technical, and commercial skills.

Project Description:

This PhD project aims to develop advanced entangled photon sources for quantum enhanced microscopy, enabling high-resolution, label-free, deep-tissue imaging. By combining mid-infrared probing with near-infrared detection, the project leverages quantum physics to overcome limitations of classical microscopy in biomedical research.

Quantum enhanced microscopy offers improved resolution, sensitivity, and speed compared to classical optical imaging, making it a promising tool for biomedical applications. This project aims to develop advanced entangled photon sources to support this emerging imaging method. Optical microscopy is widely used in biological research for visualizing tissues in their natural state. However, most current systems rely on visible or near-infrared light, which limits their ability to image deeply or without labels. In contrast, the mid-infrared spectrum contains distinct molecular vibrational and rotational signatures that can be used as a natural contrast mechanism, enabling label-free imaging. This is particularly useful for observing living tissues without altering them. A major limitation of mid-infrared imaging, however, is the lack of efficient detectors. Quantum enhanced microscopy can address this challenge. It uses pairs of entangled photons at different wavelengths: one in the mid-infrared to probe the sample, and the other in the near-infrared to carry the image information. Only the near-infrared photon is detected, taking advantage of existing high-performance detectors, while still capturing the benefits of mid-infrared imaging. This approach enables deeper tissue penetration and molecular-specific contrast without the need for direct detection of mid-infrared light. The project will focus on developing laser systems capable of generating these entangled photons efficiently for practical use in microscopy.

For more information, please contact the supervisor: Dr. Lin Xu l.xu@soton.ac.uk

Entry Requirements:

Undergraduate degree (at least UK 2:1 honours degree, or international equivalent).

Closing Date:

31 July 2026. International applicants must apply before 31 March 2026.

Funding:

See funding notes below.

How to Apply:

Please apply via the online portal and select:

• Programme type: Research
• Academic year: 2026/27
• Full time or part time
• Faculty: Engineering and Physical Sciences

Search for programme PhD Quantum Tech Eng

Please add the name of the supervisor in section 2 of the application.

Applications should include:

• your CV (resumé)
• 2 academic references
• degree transcripts/ certificates to date
• English language qualification (if applicable)