Postdoctoral researcher position (M/F) - 3 years – NF-kappaB, Proteasome, Cancer and Immunology

Positions: Postdoc Positions Application Deadline: 30 Nov 2026 - 12:00 (Europe/Paris) Country: France Type of Contract: Temporary Job Status: Full-time Hours Per Week: 35 Offer Starting Date: 1 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description We are recruiting a postdoctoral researcher for a 3-year position to work on a project aimed at identifying new therapeutic strategies targeting the NF-κB pathway in two hematological malignancies: multiple myeloma and mantle cell lymphoma . This project is funded by the French National Cancer Institute (INCa) . Our recent work has led to the identification of new NF-κB regulators associated with the ubiquitin-proteasome system , as well as the characterization by mass spectrometry of the components of supramolecular complexes discovered in the laboratory that are involved in NF-κB activation. We have also demonstrated their constitutive presence in tumor cells. Compounds identified through a pharmacological screening approach represent promising therapeutic leads, including in models of bortezomib-resistant cell lines . The project combines a fundamental research axis , aimed at gaining a better understanding of the molecular mechanisms involved in the regulation of the NF-κB signaling pathway induced by inflammatory cytokines, with an applied cancer research axis focused on identifying therapeutic targets in multiple myeloma and mantle cell lymphoma . The project may also extend to questions related to immunology, inflammation, and infection , taking advantage of the scientific environment of the CIMI and the laboratory's collaborations. The postdoctoral researcher will investigate: the molecular mechanisms and new regulators controlling NF-κB activation in response to pro-inflammatory cytokines; the composition and dynamics of NF-κB activation complexes ; the effects of the pharmacological targeting of regulators and proteins composing NF-κB-activating complexes in myeloma and lymphoma models, including bortezomib-sensitive and bortezomib-resistant models ; the relevance of these findings in samples from patients with multiple myeloma . The project benefits from a multidisciplinary research environment and collaborations with teams at the Institut Pasteur , the Toulouse Cancer Research Center (CRCT) , and clinicians from AP-HP (Assistance Publique – Hôpitaux de Paris) . Keywords: NF-κB – signaling – proteasome – ubiquitination – multiple myeloma – mantle cell lymphoma – cancer – immunology – inflammation – infection – streptococcus – CRISPR/Cas9 – proteomics – targeted therapy Website of the "Cell Signaling and Pathogenesis" team: https://cimiparis.fr/equipes/robert-weil/ Where to apply E-mail: emmanuel.laplantine@inserm.fr Requirements Research Field: Biological sciences » Biology Education Level: PhD or equivalent Skills/Qualifications We are looking for a curious, rigorous and independent researcher , with a strong team spirit and the ability to develop scientific hypotheses . The successful candidate will hold a PhD in cell and molecular biology, biochemistry, cancer biology, immunology, pharmacology, or a related field . Experience in several of the following areas is desirable: cell culture, Western blotting, immunofluorescence/microscopy, CRISPR/Cas9 (KO/KI), protein–protein interactions, cell signaling, proteomics, flow cytometry, and cell-based pharmacology . Specific Requirements Experience in several of the following areas is desirable: cell culture, Western blotting, immunofluorescence/microscopy, CRISPR/Cas9 (KO/KI), protein–protein interactions, cell signaling, proteomics, flow cytometry, and cell-based pharmacology . Languages: ENGLISH Level: Good Research Field: Biological sciences » Biology Additional Information Benefits Salary: Starting from €2,997.20 gross per month , depending on professional experience, with the possibility of a higher salary based on professional experience in equivalent positions. Monthly transport pass in Paris (75% paid by the institution) Website for additional job details: https://cimiparis.fr/en/equipes/robert-weil-2/ Work Location(s) Number of offers available: 1 Company/Institute: INSERM U1135 Country: France City: PARIS Postal Code: 75013 Street: 91 Boulevard de l'Hopital Contact City: Paris Website: https://cimiparis.fr/en/ Street: 91 Boulevard de l'Hôpital Postal Code: 75013