Job Information
- Organisation/Company: Instituto de Tecnologia Química e Biológica António Xavier ITQB NOVA
Offer Description
Instituto de Tecnologia Química e Biológica António Xavier – ITQB NOVA
Application for a Master Fellowship
within the UID/04462/2025
Applications are invited for a Master Fellowship in the scope of the project entitled “Biomarker Research Integrating Data of Glyco-Immune Signatures and Clinical Evidence in Breast Cancer (BRIDGE)” with the Ref. UID/04462/2025 (internal reference ICG15773), funded by Fundação para a Ciência e Tecnologia/MCTES (PIDDAC).
Scientific Area: Biomedical Sciences, Subarea of Cancer Research.
Academic degree: Master in Biomedical Sciences, Biochemistry, Biotechnology, or related areas, with a minimum grade of 18/20.
Other requisites:
- Experience in 3D cell culture, namely bioreactor-based tumour microenvironment (TME) models.
- Experience with gene editing and molecular biology tools, including CRISPR/Cas9 gene editing in mammalian/myeloid cells.
- Proficiency in flow cytometry analysis, including spectral flow cytometry.
- Hands-on experience with protein analysis techniques, including Western blotting and immunodetection assays.
- Experience in big data analysis, namely transcriptomics.
- Good command of the English language, both written and spoken.
- Being enrolled in a PhD or in a non-academic degree course, in accordance with the Article 6th of “Regulamento de Bolsas de Investigação da Fundação para a Ciência e a Tecnologia, I.P. from FCT”, law in force.
Working Plan: This project aims to validate the functional role of immunosuppressive lectins in tumour-associated macrophages (TAMs) using advanced bioreactor-based 3D tumour microenvironment (TME) models of HER2-positive and triple-negative breast cancer. By performing CRISPR/Cas9-mediated knockout of candidate lectins in macrophages within these 3D co-culture models, we will assess their impact on TAM polarisation, cytokine secretion and T-cell responses. The model will be used to dissect glycan-lectin signalling pathways driving immunosuppression in the breast cancer tumour microenvironment.
Applicable Law and Regulations: Status of Scientific Research Fellow, approved by Law number 40/2004, of August 18th, changed and republished by Ordinance 202/2012 of August 27th and changed by Ordinance 233/2012 of October 29th and by Law 12/2013 of January 29th and by Ordinance 89/2013 of July 9th and by the Ordinance 123/2019 of August 28th, and by the Ordinance 65/2024 of October 1st. Regulations for Research Fellowships from Fundação para a Ciência e a Tecnologia, I.P., in force (https://www.fct.pt/wp-content/uploads/2026/01/RBi_Republicado_2025.pdf).
Working Place: The work will be carried out in the Advanced Cell Models Laboratory at ITQB NOVA, under the supervision of Doctor Catarina Brito.
Duration of the fellowship: The fellowship will have a duration of twelve months, eventually renewed, expected to start in October 2026, on a full-time basis, according to the Fellowship Regulations of Fundação para a Ciência e Tecnologia, I.P.
Stipend amount: 1359.64, according to the table of values of grants awarded directly by the FCT, I.P. in the Country (https://www.fct.pt/wp-content/uploads/2026/03/Tabela-de-Valores-SMM-2026.pdf), and payment will be made monthly, through bank transfer.
Selection procedure: The evaluation procedures will be based on the analysis of the candidates´ CV and if needed, an interview for the selected candidates may take place. In this case, the curriculum evaluation and the interview will have a weight of 50 % each.
Jury composition: President of the jury: Doctor Catarina Brito, effective members: Doctor Catarina Freitas, Doctor Giacomo Domenici, substitute member: Doctor Margarida Serra.
Application documents: The application should be formalized in a cover letter indicating the corresponding fellowship reference together with the following documents: detailed Curriculum Vitae, degree certificate. All documents should be preferably sent by email in a single pdf file.
Notification of candidates: All the candidates will be informed of the final result by e-mail.
Deadlines and procedures for complaints and appeals: If the result is not favorable, the candidates have a period of 10 working days, after the disclosure of the results, to comment, if desired, in a prior hearing of interested parties, in the terms provided for in the Code of Administrative Procedure.
Application period: From 7 August to 20 August 2026.
Applications should be sent to: Catarina Brito, PhD anabrito@itqb.unl.pt Ref. 055/BI/2026 ITQB NOVA OEIRAS
Where to apply
E-mail: anabrito@itqb.unl.pt
Requirements
Research Field: Medical sciences » Cancer research
Education Level: Master Degree or equivalent
Work Location(s)
- Number of offers available: 1
- Company/Institute: ITQB NOVA
- Country: Portugal
- State/Province: Oeiras
- City: Oeiras
- Postal Code: 2780-156
- Street: Avenida da República
Contact
- State/Province: Lisboa
- City: Oeiras
- Website: http://www.itqb.unl.pt/
- Street: Av. da República
- Postal Code: 2780-156
- E-Mail: itqb.projects@itqb.unl.pt
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