"Post-Doctoral Research Associate"

The Opportunity:

We seek a postdoctoral researcher to carry out a research project to investigate novel methods to make immune-cold colorectal cancer responsive to immunotherapy.

A Cancer Research UK funded postdoctoral position is available in the lab of Dr Kevin Myant (https://institute-genetics-cancer.ed.ac.uk/research/research-groups-a-z/myant-group). The project aims to investigate how targeting RNA splicing can activate immune responses in immune-cold colorectal cancer. The project will use immune-competent mouse models, patient derived human organoid models and spatial transcriptomics to determine how cancer cells and the tumour immune microenvironment respond to RNA splicing disruption. We will utilise this data to develop novel therapeutic approaches to enhance the efficacy of immunotherapies in this disease. It would be ideally suited to a researcher with a background in immune-oncology and spatial analysis. For more information, please contact Dr Kevin Myant (kevin.myant@ed.ac.uk).

This post is fixed-term (for 36 months) with potential for a further 3-year extension based on the meeting of key objectives and full-time (35 hours per week).

The salary for this post is at Grade UE07: £41,064 to £48,822 per annum.

Your skills and attributes for success:

• A PhD in immune-oncology, cancer biology or a related biomedical field.
• Previous evidence of successful project completion, in particular first author publications.
• Experience working with animal cancer models and organoid culture systems.
• Bioinformatic experience, in particular analysis of spatial data, RNAseq analysis or experience of long read technologies.
• Ability to communicate complex information clearly.