Postdoctoral Research Associate

Newcastle University - Centre for Bacterial Cell Biology (CBCB)

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

The Role
A post is available for an experienced, enthusiastic and highly motivated Research Associate to join the laboratory of Dr Charles Winterhalter, focusing on investigating DNA damage repair mechanisms during Staphylococcus aureus infection (https://www.ncl.ac.uk/medical-sciences/people/profile/charleswinterhalter.html). This Wellcome Trust funded position is based at the Centre for Bacterial Cell Biology (CBCB) within Newcastle University Biosciences Institute.

S. aureus is the leading Gram-positive pathogen causing death from bacterial infections worldwide and is becoming increasingly resistant to our last-resort antibiotics. During infection and antimicrobial treatment, reactive oxygen species are thought to promote the introduction of DNA breaks on the bacterial genome, thereby resulting in genetic instability and cell death if not repaired. Yet despite decades of study, fundamental mechanisms underpinning bacterial clearance or survival during infection remain poorly understood. Specifically, the interplay between DNA replication, occurrence of DNA breaks and dynamics of damage repair processes are unclear.

This post will involve laboratory-based research focused on understanding bacterial DNA damage repair mechanisms in the context of infection, and in response to antimicrobial treatment. This project will combine genetics, advanced fluorescence microscopy, biochemistry and method development to decipher the molecular mechanisms enabling bacterial survival during infection.

The Winterhalter lab supports the values of a diverse, inclusive, and healthy research culture. We aim to foster a positive research environment that rewards logic, honesty, curiosity, accountability, and respect. Each member of the Winterhalter lab has their own project so that direct competition is avoided; knowledge sharing, organic collaborations, and constructive ideas are welcomed and encouraged.

This post is fixed-term for a period of 36 months, with a start date early in 2026. For informal enquiries, please contact: Charles.winterhalter@newcastle.ac.uk.

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

Qualifications

• PhD in a relevant biosciences subject.
• Master's degree in a relevant biosciences subject.
• Undergraduate degree in a relevant biosciences subject.