Postdoctoral Research Associate (Fixed Term)

University of Cambridge - Department of Clinical Neurosciences

Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced pluripotent stem cell (iPS) derived cells. The project will utilize CRISPR-Cas9 technology and other gene editing tool to achieve precise and targeted modifications of iPS-derived cells, specifically microglia and neurons. The primary aim will be the validation of new experimental targets to modulate neuro-immune interactions and halt chronic neuroinflammation. This project is part of a bigger effort aimed at modulating metabolic pathways in microglia to stop secondary neuronal damage and prevent cognitive decline (sponsor: MRC).

The ideal candidate should have:

• Ph.D. in Cell Biology, Molecular Biology, or a related field.
• Strong background in CRISPR-Cas9 technology, gene editing, and lentiviral vectors production.
• Expertise in cell culture techniques, including experience with human iPS cells (ideally iPS-derived microglia and neurons).
• Excellent data analysis and interpretation skills.
• Strong written and oral communication skills.
• Ability to work independently and as part of a team.

Additional Desirable Skills:

• Understanding of cell metabolism and metabolic pathways.
• Knowledge of bioinformatics and computational biology.
• Experience with single-cell omics technologies.
• Familiarity with databases and software for bioinformatics analyses.

The PDRA will be primarily involved in the design and execution of in vitro experiments and will be responsible for the analysis and interpretation of the obtained data (supervised by Dr. Luca Peruzzotti-Jametti, PI). The role holder may be required to assume further responsibilities in line with the role of a PDRA, in particular the supervision of students and projects within his/her area of expertise.

Thriving Multidisciplinary Environment: Immerse yourself in a vibrant research community within the Clifford Allbutt Building on the Cambridge Biosciences Campus. Benefit from close interactions with:

• Department of Clinical Neurosciences: Collaborate with leading neurologists and pre-clinical researchers, gaining access to cutting-edge clinical research and translating findings into patient care.
• Cambridge Clinical School: Engage in a rich environment with opportunities to participate in educational activities and interact with students and faculty.
• Cambridge Center for Myelin Repair (CCMR): Work alongside researchers dedicated to regenerative neurology, exploring collaborative projects focused on immunology and remyelination.
• UK Dementia Research Institute (UK DRI): Connect with researchers at the forefront of dementia research, exploring the complexities of neurodegenerative diseases and contributing to the development of new treatments and preventative strategies.

Visa payment is available for international researchers employed on a Skilled Worker or Global Talent Visa where appropriate.

Resources: https://www.LPJlab.org/

Relevant Publications:

• Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature. 2024. doi: 10.1038/s41586-024-07167-9.
• Metabolic Control of Microglia. Adv Neurobiol. 2024. doi: 10.1007/978-3-031-55529-9_34.
• Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis. Cell Stem Cell. 2024. doi: 10.1016/j.stem.2024.09.014.
• Metabolic Control of Smoldering Neuroinflammation. Front Immunol. 2021. doi: 10.3389/fimmu.2021.705920.
• Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis. Trends Mol Med. 2018. doi: 10.1016/j.molmed.2018.07.007.

Closing date
09/02/2026