Postdoctoral Research Fellow - Jones Lab

The Jones Lab is developing next-generation covalent chemical biology with the objective of expanding the druggable proteome. We seek a highly motivated individual to join our collaborative research efforts as a POSTDOCTORAL RESEARCH FELLOW who will work on chemical biology projects directed towards the development of novel therapeutic modalities.

We are based at Dana-Farber Cancer Institute in Longwood Center, and we have access to state-of-the-art facilities for chemistry, biophysics, biochemistry, structural biology, and mass spectrometry.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities:

• Develop and apply biochemical, biophysical, and cellular assays to enable the development of chemical probes suitable for cellular and in vivo pharmacological validation
• Screen compounds; analyze and interpret data
• Explore and elucidate molecular modes-of-action of chemical probes
• Maintain accurate lab records and documentation
• Contribute to publications and grant proposals.
• Stay current with scientific advances in the fields of chemical biology and screening technologies, and apply emerging techniques and insights to their own research

Qualifications and Experience:

• PhD degree in chemical biology or a related discipline
• Expert in protein preparation, biochemical assay development and compound screening
• Expert in chemical biology techniques used to assess interactions between proteins and small molecules
• Experience in cell-based assay development, compound screening and immunoblot
• Experience in chemoproteomics is desirable
• Excellent communication and presentation skills
• Evidence of consistent scientific innovation. Proven track record of publications in peer reviewed journals
• Able to work independently as well as in a collaborative team environment
• Excellent organizational and prioritization skills. Strong attention to detail
• Able to collect and analyze experimental data, prepare research publications, and communicate results