"Postdoctoral Research Scientist – Neuronal biologist in restoring lysosomal function in Parkinson’s disease"

About us:

At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.

Overview of the role:

We are seeking a Postdoctoral Research Scientist to join the Laboratory of Molecular Neurodegeneration at the Department of Physiology, Anatomy and Genetics, University of Oxford. The ideal candidate will be a motivated neuroscientist with experience in neurodegenerative disease models, lysosomal biology, and biomarker discovery. Expertise in in vivo experimentation and molecular techniques is essential, along with a collaborative and translational research mindset.

You will investigate the mechanisms of action of novel lysosomal modulators in transgenic mouse models of Parkinson’s disease, assess therapeutic efficacy, and identify biomarkers of lysosomal activity. This post is available for 24 months.

Key responsibilities:

• Testing small molecule drugs targeting lysosomal function
• Biomarker analysis in mouse models
• Biochemistry, immunohistochemistry, and neuropathology on brain tissue
• Genotyping, breeding, and mouse line maintenance
• Contributing to research development and publications

Selection criteria:

• PhD/DPhil in neuroscience or molecular biology (or near completion)
• Experience with transgenic mouse models and brain tissue analysis
• UK Home Office personal licence (or willingness to obtain)
• Strong motivation, creativity, and commitment to equality, diversity, and inclusion

What we offer:

Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including:

• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle and electric car loan schemes
• Employee Assistance Programme
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans

How to apply:

Please provide a supporting statement outlining how you meet the selection criteria along with your CV, and the details of two referees as part of your online application.

The closing date for applications is 12 noon on Friday 5th December.

Interviews are likely to take place during the week commencing 15th December and will be either face to face or held on Microsoft Teams.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

Stay connected with us on LinkedIn, Bluesky and Instagram to learn more about our work and culture. Informal enquiries about the role may be directed to the DPAG HR Team: hr@dpag.ox.ac.uk