"Professional Research Assistant, Senior Professional Research Assistant, Research Associate (0.6 FTE)"

Professional Research Assistant, Senior Professional Research Assistant, Research Associate (0.6 FTE)

University of Colorado Anschutz Medical Campus

Department: Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences

Job Title: Professional Research Assistant, Senior Professional Research Assistant, Research Associate (0.6 FTE)

Position #: 00818051 - Requisition #37011

Job Summary:

The Department of Pharmaceutical Sciences is currently seeking a highly motivated and skilled Professional Research Assistant or Research Associate to support Dr. Kristofer Fritz and his Lab in their groundbreaking research in the Department of Pharmaceutical Sciences at the University of Colorado, Anschutz Medical Campus, Aurora, CO.

This position's primary purpose is to conduct research for extramurally funded scientific studies. In particular, the research focus for this position is the study of alcohol-associated liver disease through the use of rodent, cell culture, and translational models. Various proteomic and epigenetic techniques are used to investigate alterations in post-translational modification (PTM) of hepatic proteins, specifically within metabolic and redox-dependent pathways. Specific duties include animal handling, enzyme assays, 1D- & 2D-SDS-PAGE, Western blotting, LC-MS/MS sample preparation and method development. The researcher will aid with day-to-day operations of the laboratory, including management of graduate students and undergraduate researchers. Experience in developing research protocols focused on the quantitative analysis of metabolically derived PTMs is highly desired. Special emphasis is placed on skills in animal handling coupled with therapeutic modalities, bioinformatics, and processing tissue samples for LC-MS/MS analysis.

Key Responsibilities:

• Conducts experiments using various proteomics techniques to investigate alterations in post-translational modification of proteins due to metabolic toxicity. Specific duties include animal handling, enzyme activity assays, 1D SDS-PAGE, Western blotting, immunohistochemistry, and assistance with day-to-day operations of the laboratory.
• Special emphasis is placed on skills in molecular biology techniques and processing murine tissues for analysis.
• Method development in advanced HPLC-MS/MS techniques, particularly for PTM capture and detection (immunoprecipitation and click-chemistry).
• Compiles and records observed experimental results, analyzes and interprets data, and documents results used to support manuscripts and grant applications.
• Collaborates with the principal investigator and other research staff to review scientific literature and develop experimental protocols.
• Keeps up to date on lab related research and technical advancements.

Work Location: Onsite - this role is expected to work onsite and is located in Aurora, CO.

Qualifications:

Minimum Qualifications:

Applicants must meet minimum qualifications at the time of hire.

This is an open rank position and could be categorized as PRA, Sr. PRA, or Research Associate based on experience and qualifications as indicated below:

Professional Research Assistant Minimum Qualifications:

• Bachelor's degree in Biochemistry, Chemistry, or a closely related field

Preferred Qualifications:

• Experience working with animal handling, Western blotting, HPLC-MS/MS, and enzyme assays
• Experience working in a research laboratory setting

Senior Professional Research Assistant Minimum Qualifications:

• Master's degree in Biochemistry, Chemistry, or a closely related field

Preferred Qualifications:

• Experience working with animal handling, Western blotting, HPLC-MS/MS, and enzyme assays
• Experience working in a research laboratory setting

Research Associate Minimum Qualifications:

• PhD degree in life sciences or a closely related field

Preferred Qualifications:

• Experience working with animal handling, Western blotting, HPLC-MS/MS, and enzyme assays
• Experience working in a research laboratory setting

Knowledge, Skills and Abilities:

• Knowledge of Biochemistry and Molecular Biology
• Proteomics and Mass Spectrometry
• Data Collection and Analysis
• Experimental Design
• Basic Science Techniques
• Data Processing, Spreadsheet, and Word Processing Computer Skills
• Ability to Work Independently
• Reasoning Ability
• Planning and Organizing Skills
• Written/Verbal Communication Skills

Anticipated Pay Range:

HIRING RANGE (0.6 FTE):

PRA: $29,046 - $39,038

Sr PRA: $35,152 - $47,290

RA: $37,724 - $50,701