Research Associate in Hydrogen Deuterium Exchange Mass Spectrometry of Membrane Proteins

The University of Manchester - School of Biological Sciences

Location: Manchester

Salary: £37,694 to £46,049 per annum, depending on relevant experience

Hours: Full Time

Contract Type: Fixed-Term/Contract

Placed On: 21st August 2025

Closes: 3rd September 2025

Job Ref: BMH-029573

We are looking for a mass spectrometrist and/or analytical chemist who is self-motivated, highly organised and works as part of a team. The project involves the development of HDX-MS strategies to study the structure and dynamics of bacterial secretesome. In particular, the project will develop the hydrogen deuterium exchange mass spectrometry (HDX-MS) technology to interrogate the conformational dynamics of multi-proteins complexes involved in bacterial translocation and within their native environment.

Essential skills and duties include:

• Hands on experience on HDX-MS of membrane proteins
• Experience in working with robotic systems for HDX workflows
• Excellent technical skills in sample preparation and HDX-MS data analysis
• Extensive and up-to-date theoretical and practical knowledge in working with membrane proteins
• Extensive experience in working with membrane proteins and developing related methods
• Working with other laboratory members to develop methods and contribute in maintaining equipment
• Writing high-quality research papers

What you will get in return:

• Fantastic market leading Pension scheme
• Excellent employee health and wellbeing services including an Employee Assistance Programme
• Exceptional starting annual leave entitlement, plus bank holidays
• Additional paid closure over the Christmas period
• Local and national discounts at a range of major retailers

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

Hybrid working arrangements may be considered.

Enquiries about the vacancy, shortlisting and interviews: Name: Dr Argyris Politis, Email: argyris.politis@manchester.ac.uk

General enquiries: Email: People.recruitment@manchester.ac.uk