"Research Scientist"

Job Description

The Sahoo Lab is seeking a Research Scientist to help develop and lead our research program focused on the genetic and functional mechanisms driving bone marrow failure, clonal hematopoiesis, and progression to MDS/AML. The Research Scientist will have the opportunity to pursue an independent project while also contributing to collaborative efforts across the group, including mentoring and training junior scientists.

Our lab uses patient-derived samples, iPSC models, CRISPR-based genome editing, single-cell multi-omics, and mouse disease models to uncover how germline and acquired genetic changes including mutations, and chromosomal aneuploidy shape hematopoietic stem cell fate and leukemogenesis.

Available projects include:

1. Germline predisposition to MDS/AML: Defining the mechanisms by which germline SAMD9L mutations cause hematopoietic failure and predispose to leukemogenesis.
2. Chromosome 7 aneuploidy syndromes: Modeling monosomy 7–associated bone marrow failure and understanding its contribution to clonal selection.
3. Clonal evolution and therapeutic vulnerabilities: Using single-cell sequencing platforms to track clonal evolution and identify novel therapeutic targets in high-risk MDS/AML.

The Research Scientist will have access to Virginia Tech and Children’s National Hospital resources, core facilities, and seminars, and will be provided strong opportunities for career growth and development. Our team actively supports diverse career trajectories and encourages leadership training, networking, conference participation, and skill development. This is an exciting opportunity to play a foundational role in shaping a new lab at the Research and Innovation Campus in Washington, DC.

Required Qualifications

• Ph.D. in a biological science such as hematology, genetics, molecular biology, or cancer biology,
• Demonstrated postdoctoral research experience with strong publication record
• Strong expertise in experimental design and execution
• Proficiency in wet lab techniques, including molecular biology and mammalian cell culture
• Hands-on experience working with primary cells such as iPSCs and hematopoietic stem cells
• Experience with CRISPR-based genome editing and functional screens
• Self-motivated, creative, and detail-oriented researcher
• Excellent organizational and time management skills
• Ability to work independently and as part of a collaborative team
• Experience mentoring or training students and/or research staff
• Excellent communication skills

Preferred Qualifications

• Experience with mouse models of hematopoiesis or cancer
• Familiarity with single-cell multi-omics approaches
• Analysis of large scale genomic and/or transcriptomics data sets

Overtime Status

Exempt: Not eligible for overtime

Appointment Type

Restricted

Salary Information

Commensurate with experience

Hours per week

40+

Review Date

10/21/25

Additional Information

The successful candidate will be required to have a criminal conviction check.