"Senior Research Technician/Lab Manager, McCormick Lab"

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

The Lauren McCormick Lab investigates how the cell's microtubule cytoskeleton assembles, specializes, and evolves using both simulations and experiments. By studying these fundamental molecular machines, microtubules built from alpha- and beta-tubulin proteins, the lab seeks to answer open questions about how microtubules adapt and specialize in human cells and across diverse organisms. We aim to uncover how tubulin mutations contribute to human diseases, filling key gaps in our understanding of microtubule function and cytoskeletal disorders. The Research Laboratory Technician Senior provides essential technical lab support by performing complex laboratory and research-related tasks, and acting as a specialist on laboratory methods and equipment. Performs a variety of molecular biology techniques requiring a high degree of proficiency, also troubleshoots problems and recommends solutions. Evaluates experiment results using statistical analysis. May instruct graduate students and postdocs in laboratory techniques, instruments, and procedures.

The McCormick Lab is part of the Program in Biophysics. Biophysicists at Michigan are working in the fields of Structural Biology, Spectroscopy and Microscopy, Computational Biophysics and Bioinformatics, and Biophysical Chemistry. Approximately 80 graduate students, post-docs, and professors work in our well-equipped laboratories. The graduate program offers a flexible curriculum of exciting courses related to these fields, taking advantage of the resources available at a major research University.

• Perform research independently or supervised, providing data for manuscripts and grants.
• Analyze data using statistical approaches to find statistically significant differences.
• Analyze and present your work, and journal articles, at lab meeting.
• Assist graduate students and postdoctoral researchers with routine laboratory procedures like protein purification, plasmid preps, cell culture, western blotting, PCR, and SDS-PAGE electrophoresis.
• Maintain lab equipment, purchase lab supplies, restock the lab and assist with ordering.
• Maintain routine cell cultures

Required Qualifications

• Bachelor's Degree with 1-3 years' experience required. A strong interest in and commitment to advancing our understanding of cytoskeletal function is essential.
• Prior experience with protein purification (FPLC system) is required.
• Prior experience with nucleic acid extraction (plasmid preps, routine PCR)
• Prior experience with cell culture is required.

Preferred Qualifications

• Experience with baculovirus systems and insect cell culture. Experience with bacmid nucleic acid preps.
• Experience developing and troubleshooting protein purification workflows.
• Experience making competent cells and cell stocks

40 hours per week, full-time, Monday through Friday.