"Staff Scientist - Nephrology"

Position Summary

The Mahjoub laboratory studies the role of the cell cytoskeleton in regulating cell physiology, tissue formation, and organ development, with specific focus on microtubule-based organelles called centrosomes and cilia. Our aim is to determine the consequences of centrosome-cilia defects in the development of human ciliopathy syndromes, with specific focus on renal and pulmonary ciliopathies. 

This specific project involves characterization of centrosome defects and how they cause cystic kidney disease. The experiments involve multiple systems and tools including primary cell cultures and organoids, transgenic mice, advanced microscopy techniques (Superresolution, ultrastructure expansion, electron, and live-cell imaging), as well as standard molecular and biochemical laboratory methods.

Designs research protocols. Assists in developing and conducting research projects, including experiment design, data analysis and documentation of experiment results.

Job Description

Primary Duties & Responsibilities:

• Following instructions and discussions with the principal investigator, designs research protocols, including developing procedures for the collection, verification and management of data.
• Assists with grant preparation and reporting.
• Performs complex statistical analysis of data collected and writes interpretative reports. Verifies the correctness of the data submitted and makes recommendations based on these analyses.
• Documents research topics and prepares and submits papers based on research work to publications and committees for publication or presentation to peers.
• Solves practical problems relating to difficulties with equipment or test subjects. Suggests technical or procedural improvements in testing methods.
• Conducts literature searches related to research project.
• Performs other duties as assigned.

Working Conditions:

• Works in a laboratory environment with potential exposure to biological and chemical hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Master’s degree or combination of education and/or experience may substitute for minimum education.

Certifications/Professional Licenses:

No specific certification/professional license is required for this position.

Work Experience:

Laboratory Operations (3 Years)

Preferred Qualifications:

• Extensive experience using preclinical mouse models of human disease. This includes handling mice, genotyping/phenotyping, drug administrations in mice, etc.
• Isolation of organs, tissues and other samples from mice, and analysis by these specimens by histology and other methods.
• Prior training in mammalian cell culture and/or organoid systems.
• Experience with immunofluorescence microscopy.

Education:

Ph.D. - Doctor of Philosophy

Skills:

Analytical Problem Solving, Communication, Computer Literacy, Data Analysis, Data Interpretations

Grade

R10

Salary Range

$48,000.00 - $86,900.00 / Annually