Rate My Professor Gregoire Lauvau

Gregoire Lauvau, Ph.D., is a Professor in the Department of Microbiology & Immunology at Albert Einstein College of Medicine, holding the Sylvia and Robert S. Olnick Faculty Scholar in Cancer Research position. He has been at the institution since 2009. His research specializes in the functional differentiation of naive and memory CD8+ T cells, exploring the influence of cognate antigen on their functional fates and host protective roles. Lauvau studies the generation of functionally and epigenetically distinct memory CD8 T cell subsets and seeks to harness these for T cell therapies.

In anti-tumor immunity, he employs a novel mammary stem-cell based breast cancer model with clinically relevant mutations to investigate immune escape mechanisms and anti-tumor therapies, including in HTLV1+ acute T cell lymphoma patients. His malaria immunity research highlights circulating cytolytic memory CD4 T cells in protected patients, using CyTOF, single-cell analyses for antigen specificity, and mouse models for Plasmodium falciparum protection. The lab develops recombinant pathogens, engineered mice, T cell engineering tools, and applies transcriptomics, single-cell transcriptomics, lentiviral engineering, epigenetics, and intravital microscopy to uncover orchestrators of protective immune responses against pathogens and tumors, enabling rational design of immune cell therapies.

Key publications include: Mutations in MLL3 promote breast cancer progression via HIF1a-dependent recruitment and differentiation of regulatory T cells into tumors (Immunity, 2025); Cytolytic memory CD4+ T cell clones are expanded during Plasmodium falciparum infection (Nature Communications, 2023); A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression (Developmental Cell, 2023); CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice (eLife, 2022); Memory CD8+ T cells mediate early pathogen-specific protection via localized delivery of chemokines and IFNg to clusters of monocytes (Science Advances, 2021).