Rate My Professor Xiaoxin Hao

Xiaoxin Hao is a Principal Investigator and Assistant Professor at the Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College. He serves as the Principal Investigator of the National Key Laboratory of Immunity and Inflammation. Hao obtained his PhD in Basic Medicine from Shanghai Jiao Tong University School of Medicine in 2019. Prior to his current role, he completed postdoctoral training from 2019 to 2024 as a Postdoctoral Fellow in the laboratory of Xiang H.-F. Zhang at the Lester and Sue Smith Breast Center, Baylor College of Medicine, United States. His career trajectory reflects a commitment to advancing cancer research through interdisciplinary approaches in immunology and hematopoiesis.

Hao's research focuses on tumor-hematopoietic crosstalk and its role in regulating cancer immunity, metastasis, and systemic immunosuppression. His studies elucidate how solid tumors, particularly breast cancers, reprogram myeloid cells, neutrophils, and B cells to promote immune evasion and therapy resistance, involving mechanisms such as arachidonic acid metabolism and osteoprogenitor-granulocyte-monocyte progenitor interactions. Key publications include "Osteoprogenitor-GMP Crosstalk Underpins Solid Tumor-Induced Systemic Immunosuppression and Persists After Tumor Removal" (Cell Stem Cell, 2023), "Solid Tumour-Induced Systemic Immunosuppression Involves Dichotomous Myeloid–B Cell Interactions" (2024), "Tumor-Derived Arachidonic Acid Reprograms Neutrophils to Promote Immune Suppression and Therapy Resistance in Triple-Negative Breast Cancer" (Immunity, 2025), "Inflammation- and Resolution-Programmed Myeloid Circuits Govern Therapeutic Resistance in Epithelial and Mesenchymal Triple-Negative Breast Cancer" (2026), and earlier works such as "Metabolic Imaging Reveals a Unique Preference of Hypoxic Tumor Cells for Glycolysis" (Cell Metabolism, 2019) and "Oxidative Phosphorylation Enhances the Leukemogenic Capacity" (Science Advances, 2021). With over 900 citations on Google Scholar, Hao's contributions have influenced understandings of tumor microenvironments and therapeutic strategies. He has been honored as a National Youth Talent.