"Bioinformatician / Senior Bioinformatician (Crossley Group) (Fixed Term)"

We are seeking an experienced Bioinformatician to help establish and lead the computational side of a new, growing group.

The Crossley research group (https://www.cruk.cam.ac.uk/research-groups/crossley-group/) studies RNA-DNA hybrid molecules called R-loops - how they are dysregulated in human disease, drive genome instability and inflammation, and how these molecules and cellular responses to them can be harnessed for cancer detection & treatment. We use biochemical, imaging and genomics approaches to study molecular mechanisms underlying R-loop biology and their clinical applications.

You will lead computational projects, build and optimize data analysis pipelines and collaborate with and mentor group members. The work will focus mainly on the analysis of large-scale genomics datasets, mainly RNA-DNA hybrid sequencing (cellular and extracellular) and RNA/ChIP/ATAC-seq, to support our discovery and translational research. A deep understanding of biological principles is essential, to generate hypotheses and mechanistic insight from our data and help guide experimental design.

You will have a Master's or PhD in Bioinformatics (or related field) & extensive experience, including a variety of programming languages and platforms, analysis of genomics datasets in an academic setting, and a robust understanding of statistics. Strong critical thinking and independence is required, to work with first-in-class sequencing data from RNA-DNA hybrids from biological and clinical samples, and to help develop new hybrid sequencing methods (e.g. single-cell and long-read).

As the bioinformatics lead of a new research group, a willingness and ability to set up effective & durable bioinformatics codebases, including version control and reproducible analysis pipelines, is essential. Experience with and willingness to leverage and build upon existing open-source solutions is highly desirable. You will work collaboratively with Dr. Crossley and other group members who will generate sequencing data, and lead interactions with computational and AI scientists and bioinformaticians in other research groups, and the bioinformatics core facility.

Fixed-term: The funds for this post will be available for two years in the first instance, with the possibility to extend.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) and a security check.

If you have any queries regarding the application process or queries relating to this vacancy, please contact: mailbox-hr@cruk.cam.ac.uk.

To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/52619.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing date: 21st September 2025

Interviews are expected to take place on or around 1st October.