Academic ConnectTwo postdoctoral positions in translational cancer research
The Baslan Lab at the Department of Biomedical Sciences, the University of Pennsylvania is recruiting two Postdoctoral researchers to join our multidisciplinary team of investigators. Our work focuses on studying a unique class of cancer associated somatic mutations termed Copy Number Alterations (CNAs). These somatic events change the number and composition of chromosomes in cancer cells to yield biology that is almost entirely unknown. To dissect these events, we employ a systems biology, top-down approach where advanced analytics of large datasets are coupled to focused perturbations (ex: shRNA, CRISPR, cDNA screens) in experimental model systems. More specifically, to test biological hypotheses, our group develops and applies:
(1) advanced sequencing technologies at single cell and bulk levels to generate large multi-model datasets.
(2) novel algorithms and computational approaches based on considerations of maths, statistics, and machine learning to nominate novel cancer genes.
(3) innovative, molecularly engineered model systems in in-vitro and in-vivo settings e.g. mouse models
(4) highly parallel perturbation approaches.
Our aim is to develop early diagnostic and prognostic tools as well as to advance novel therapeutics; targeted as well as immunotherapy.
Disease areas of focus include, but are not limited to, acute leukemias, sarcomas, as well as breast and pancreatic cancers.
The two postdoctoral positions as distinct in focus and require different qualification as follows:
Postdoctoral Position 1:
Focus: Dissecting acute leukemia genetics and biology using next generation lineage tracing mouse models.
Qualifications:
• PhD degree in biomedical sciences with interest and expertise in studying the immune system.
• Required technical skills: advanced working knowledge of mouse experimentation and flow cytometry (as well as a solid background in biochemistry).
• Additional relevant skills (not required): computational analysis and proteomics.
Postdoctoral Position 2:
Focus: Exploring protein translation dysregulation in cancer
Qualifications:
• PhD degree in biomedical sciences with interest and expertise in studying cancer pathology.
• Required technical skills: advanced working knowledge of multimodal interrogation of clinical tissue (ex: histopathology and sequencing) and functional, perturbation-based biology (as well as a solid background in molecular biology).
• Additional relevant skills (not required): fluorescence microscopy and computational analysis.
Interest applicants are requested to email the following material to Dr. Baslan at https://apptrkr.com/5515793
1. CV
2. Cover letter
3. a list of 3 referees
To apply, visit https://apptrkr.com/5515793
Copyright ©2024 Jobelephant.com Inc. All rights reserved.
Tell them AcademicJobs.com sent you!
