Postdoc in immunology and single-cell genomics at Yale University

Job Details

The Ya-Chi Ho Lab at Yale University (https://medicine.yale.edu/lab/yachiho/) investigates viral-host interactions, T cell biology, and immune therapeutics in chronic viral infection, cancer, and aging. The lab works on viral genomics, T cell immunology, human pathophysiology, and therapeutic strategies using tools involving immunology, molecular biology, single-cell multiomics, and spatial transcriptomics in both human clinical samples and mouse models.

We are recruiting highly motivated, curios, and collegial postdocs to lead independent, hypothesis-driven projects using multi-disciplinary approaches for mechanistic interrogations.

Potential projects may include:

• Genome-wide Perturb-seq (involving CRISPR activation and inhibition) or single-cell multi-omic screens to dissect the impact of HIV infection on the cell fate decisions of T cells
• Immune engineering, including targeting transcription factor BACH2 to enhance CAR-T cell efficiency, anti-viral immunity, and cancer immunity
• The impact of viral-host interactions in tissues, particularly the lymph node, the gut, and the tumor microenvironment

The projects may involve molecular cloning, mammalian cell culture, flow cytometry, clinical sample processing under BSL2+ containment, single-cell multi-omics, spatial transcriptomics, bioinformatics, organoid culture, and validation in mouse models.

Required qualifications:

• Received a PhD within 4 years or are about to graduate from a PhD program,
•  AND
• Have first-authored original publication(s) in high-quality peer-reviewed journals.
• While we conducts advanced bioinformatic analysis in-house, mechanistic interrogations are required. Candidates seeking dry-lab only research should not apply to this position.

Preferred qualifications:

• Experiences in immunology, mammalian cell culture, mouse models, molecular cloning, or bioinformatics are preferred.

To apply:

• Email ya-chi.ho@yale.edu with: CV, contact information of 3 referees, and a personal statement describing why this lab is interesting to you.