PostDoc Research Fellow - Gut Microbiology - Theriot Lab

Company: North Carolina State University

Job Location: Raleigh, North Carolina

Category: Biochemistry and Molecular Biology

Type: Full-Time

Join the Pack! A community with nearly 8,000 faculty and staff, and 30,000 students. NC State is one of the largest employers in North Carolina, offering a large range of career opportunities. Visit us at https://jobs.hr.ncsu.edu/.

Position Number: 00111522

Essential Job Duties: A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot's group at North Carolina State University College of Veterinary Medicine (NCSU CVM).

Duties and Responsibilities The successful applicant will characterize bacteria (Enterobacteriaceae) for their ability to alter bile acids, lipids, and compete against C. difficile for the same nutrients. The scholar will also bioengineer bacterial proteins to manipulate bile acid and amino acid metabolism in the gastrointestinal tract. The Theriot laboratory (https://theriotlab.org) studies how the gut microbiota is able to provide colonization resistance against enteric pathogens, specifically C. difficile. They seek to define the mechanisms that provide protection by looking at the dynamics between the gut microbiota, metabolome, and host using in vitro, ex vivo, and in vivo models. This will aid in the design of targeted therapeutics against C. difficile, but more importantly the design of precision probiotics to manipulate the gut microbiota.

Requirements: Applicants are expected to have obtained a PhD in a field related to microbiology, biochemistry, to have strong computational and communication skills, and to be interested in collaborative research. Applicants with a background in bacterial and protein engineering, anaerobic bacterial physiology, Enterobacteriaceae physiology, and/or microbiology of infectious diseases are highly encouraged to apply. Experience characterizing bacteria and proteins for biotechnological applications, mouse models of disease, and knowledge in gut microbiome analysis and other omics is desirable. Research efforts will contribute toward publications, presentations and other funding opportunities. The selected individual will be expected to have effective communication skills, both with the PI and students within the laboratory, and will be expected to work well independently and within a team.

Departmental Required Skills: Prior research experience; Strong verbal and written communication skills; Excellent organizational skills with strong attention to detail; Ability to adhere to tight deadlines, goal oriented, and high level of motivation; Ability to work independently and as part of a team; Computer literacy with Microsoft offices and data analysis software (R studio is a plus).

Preferred Experience, Skills, Training/Education: N/A

Necessary Licenses or Certifications: N/A

Department: 196001 - Department of Population Health and Pathobiology

Location: Raleigh, NC