Postdoctoral Research Associate

Queen Mary University of London - Barts Cancer Institute

About the Role

We are seeking a postdoctoral research assistant to join the group of Dr Mirjana Efremova in the Centre for Cancer Evolution, to investigate epigenetic regulators driving therapy resistance in colorectal cancer using patient-derived organoids co-cultured with myeloid cells. Our lab is focused on understanding the cellular and molecular mechanisms promoting metastasis and therapy resistance in colorectal cancer. We use single-cell multiomics and spatial transcriptomics data from patient samples and patient-derived organoids (Ogden et al., Cell Genomics 2025, Efremova et al. Nature; Efremova et al., Cell Reports) and develop computational methods (Efremova et al. Nature Protocols, 2020; Jain et al., Genome Biology).

About You

PhD in a biological or computational subject and background in working with genomics data.

About the Institute

The Barts Cancer Institute (BCI) is a Cancer Research UK Centre of Excellence whose work aims to transform the lives of those with and at risk of cancer through innovative research in the laboratory, in patients and in populations. BCI is internationally renowned in many areas of cancer research and it combines ground-breaking basic research with the expertise of clinicians and clinician scientists from the Centre for Experimental Cancer Medicine and the Barts NHS Trust to achieve improvements in cancer patient care. BCI is also a partner in the CRUK City of London Major Centre (together with UCL, Kings and the Francis Crick Institute) which is a Centre of Excellence in Biotherapeutics. BCI is committed in supporting and developing future cancer researchers through its extensive postgraduate training.

About Queen Mary

At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.

Throughout our history, we’ve fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it’s simply ‘the right thing to do’ but for what it helps us achieve and the intellectual brilliance it delivers.

We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.

Benefits

We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements, and campus facilities.

The post is based at the Charterhouse Square campus in London. It is full time (35 hours per week), fixed term appointment for 3 years. The starting salary will be Grade 4, SP 25-33 in the range of £38,419 - £46,618 per annum, inclusive of London Allowance.

Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointments processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to considering applications from candidates wishing to work flexibly.