"Postdoctoral Scientist – RNA dynamics in cancer"

About the role:

A postdoctoral position is available in the laboratory of Sylvain Delaunay to study how diet affects RNA modifications to drive cancer progression. To this end, xenotransplantation models and multimodal molecular profiling techniques will be used, combined with diverse bioinformatics approaches, centred around RNA biology (i.e., CRISPR-screen, Ribo-seq, RNA-seq, Nanopore-seq). Besides biological material coming from primary cell lines and in vivo mouse models, we will also have access to patient samples to use as discovery and validation of our findings.

About you:

You are adept at problem-solving, working proactively, and meeting competing deadlines effectively. You should hold a PhD in Molecular Biology, Cell Biology, Pharmacy or a related discipline. A background in RNA biology and mRNA translation is desirable but not required. You should have an excellent academic track record for publications. You will have excellent organisational skills, strong attention to detail, and the ability to work collaboratively as part of a team. A current or previous holder of a Personal Licence (PIL A & B) or equivalent under the Animals (Scientific Procedures) Act 1986, as well as experience in CRISPR-screen is preferrable. Applications from candidates with exceptional bioinformatics skills who are eager to gain hands-on wet lab experience are also welcome.

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute is a world-leading centre for excellence in cancer research. It is core funded by Cancer Research UK and partnered with The Christie NHS Foundation Trust, providing an exceptional environment for research programmes.

How to apply?

For any informal enquiries about this post, please contact Sylvain Delaunay at sylvain.delaunay@cruk.manchester.ac.uk. Please note this vacancy will close for applications at 11:59pm on the closing date specified. Online interviews will take place from 10th-14th November 2025.