Research Assistant - Lysosomal dysfunction in Parkinson’s disease

University of Oxford - Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery

Location: Oxford

Salary: £34,982 to £36,616 per annum

Hours: Full Time

Contract Type: Fixed-Term/Contract

Placed On: 18th August 2025

Closes: 5th September 2025

Job Ref: 181611

Contract & job type: Full-time, Fixed-term until 30 June 2026

About us: At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.

Overview of the role: We are seeking a Research Assistant to join our team on a translational project investigating lysosomal dysfunction in Parkinson’s disease. The ideal candidate will have experience with iPSC cultures, a background in cellular neuroscience or molecular cell biology, and a meticulous approach to lab work and data handling. You will help develop biomarkers, test therapeutic compounds, and contribute to assay development using iPSC-derived dopamine neurons from Parkinson’s patients. This post is available immediately until 30 June 2026. Funded by the Michael J Fox Foundation and in collaboration with EndLyz (Dementia Discovery Fund portfolio), this project offers a unique opportunity to work across academic and pharmaceutical research.

Key responsibilities:

• Laboratory experiments and data interpretation
• Imaging analysis and assay read-outs
• iPSC-derived neuron and cell line studies
• Data preparation for publication
• Project planning and methodology development
• Academic–industry collaboration

Selection criteria:

• BSc/MSc in a relevant area of research (or near completion)
• iPSC culture experience
• Neurodegenerative disease model knowledge
• Problem-solving and innovation skills
• Attention to detail and record keeping
• Understanding of neuronal phenotypes

What we offer: Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including: An excellent contributory pension scheme, 38 days annual leave, A comprehensive range of childcare services, Family leave schemes, Cycle and electric car loan schemes, Employee Assistance Programme, Membership to a variety of social and sports clubs, Discounted bus travel and Season Ticket travel loans. While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

How to apply: Please provide a supporting statement outlining how you meet the selection criteria along with your CV, and the details of two referees as part of your online application. The closing date for applications is 12 noon on Friday 5th September. Interviews are likely to take place during the week commencing 8th or 15th September. Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.